ArticleGenes, brain, and behavior2008
Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays.
Article in Genes, brain, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.Molecular psychiatry · 2014Pooled it
- Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma.PloS one · 2011Pooled it
- Examination and Comparison of Cognitive and Executive Functions in Clinically Stable Schizophrenia Disorder, Bipolar Disorder, and Major Depressive Disorder.Depression research and treatment · 2020Article
- Genomic prediction of cognitive traits in childhood and adolescence.Molecular psychiatry · 2019Article
- Genes, Cells and Brain Areas of Intelligence.Frontiers in human neuroscience · 2019Review
- Moderating effect of mode of delivery on the genetics of intelligence: Explorative genome-wide analyses in ALSPAC.Brain and behavior · 2018Article
- The new genetics of intelligence.Nature reviews. Genetics · 2018Review
- The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay.Psychological bulletin · 2018Review
- Neurocognitive function in clinically stable individuals with long-term bipolar I disorder: Comparisons with schizophrenia patients and controls.The Kaohsiung journal of medical sciences · 2017Article
- Intelligence as a Developing Function: A Neuroconstructivist Approach.Journal of Intelligence · 2017Article
- A genome-wide association study of essential hypertension in an Australian population using a DNA pooling approach.Molecular genetics and genomics : MGG · 2017Article
- A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence.Molecular psychiatry · 2016Article
- Toward an integrative science of the developing human mind and brain: Focus on the developing cortex.Developmental cognitive neuroscience · 2016Article
- Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait.European journal of human genetics : EJHG · 2015Article
- Neuron-based heredity and human evolution.Frontiers in neuroscience · 2015Review
- Genome-wide association study of receptive language ability of 12-year-olds.Journal of speech, language, and hearing research : JSLHR · 2014Article
- Results of a "GWAS plus:" general cognitive ability is substantially heritable and massively polygenic.PloS one · 2014Article
- Low-Frequency Copy-Number Variants and General Cognitive Ability: No Evidence of Association.Intelligence · 2014Article
- Neuropsychological impairments in schizophrenia and psychotic bipolar disorder: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study.The American journal of psychiatry · 2013Article
- Exceptional memory performance in the Long Life Family Study.Neurobiology of aging · 2013Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
General cognitive ability (g), which refers to what cognitive abilities have in common, is an important target for molecular genetic research because multivariate quantitative genetic analyses have shown that the same set of genes affects diverse cognitive abilities as well as learning disabilities. In this first autosomal genome-wide association scan of g, we used a two-stage quantitative trait locus (QTL) design with pooled DNA to screen more than 500,000 single nucleotide polymorphisms (SNPs) on microarrays, selecting from a sample of 7000 7-year-old children. In stage 1, we screened for allele frequency differences between groups pooled for low and high g. In stage 2, 47 SNPs nominated in stage 1 were tested by individually genotyping an independent sample of 3195 individuals, representative of the entire distribution of g scores in the full 7000 7-year-old children. Six SNPs yielded significant associations across the normal distribution of g, although only one SNP remained significant after a false discovery rate of 0.05 was imposed. However, none of these SNPs accounted for more than 0.4% of the variance of g, despite 95% power to detect associations of that size. It is likely that QTL effect sizes, even for highly heritable traits such as cognitive abilities and disabilities, are much smaller than previously assumed. Nonetheless, an aggregated 'SNP set' of the six SNPs correlated 0.11 (P < 0.00000003) with g. This shows that future SNP sets that will incorporate many more SNPs could be useful for predicting genetic risk and for investigating functional systems of effects from genes to brain to behavior.
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