SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Influence of osteoporosis on fracture fixation--a systematic literature review.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- Increased risk of osteoporosis among thyroid cancer survivors: the influence of postoperative levothyroxine therapy in a nationwide cohort study.Annals of surgical treatment and research · 2026Article
- Secondary Displacement was Common in Healing Distal Femur Fractures in a Cohort of Elderly Patients.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- A new scoring system for predicting cut-out risk in patients with intertrochanteric femur fractures treated with proximal femoral nail anti-rotation.Acta orthopaedica et traumatologica turcica · 2023Article
- Decellularized vascularized bone grafts as therapeutic solution for bone reconstruction: A mechanical evaluation.PloS one · 2023Article
- How relevant is lumbar bone mineral density for the stability of symphyseal implants? A biomechanical cadaver study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Evaluation of mushroom-shaped allograft for unstable proximal humerus fractures.Archives of orthopaedic and trauma surgery · 2022Article
- Complications and Difficulties Encountered in the Management of a Neglected Osteoporotic Proximal Humerus Fracture.Journal of orthopaedic case reports · 2022Article
- Comparison Between Femoral Neck Systems and Cannulated Cancellous Screws in Treating Femoral Neck Fractures: A Meta-Analysis.Geriatric orthopaedic surgery & rehabilitation · 2022Article
- Generation of Vertebra Micro-CT-like Image from MDCT: A Deep-Learning-Based Image Enhancement Approach.Tomography (Ann Arbor, Mich.) · 2021Article
- [Research progress on intra-articular screw penetration in proximal humeral fracture treated with locking plate].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Review
- Comparison of unilateral and bilateral polymethylmethacrylate-augmented cannulated pedicle screw fixation for the management of lumbar spondylolisthesis with osteoporosis.Journal of orthopaedic surgery and research · 2020Article
- Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals.Scientific reports · 2020Article
- Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation.Bone research · 2019Review
- Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing.Frontiers in immunology · 2019Article
- Time to augment?! Impact of cement augmentation on pedicle screw fixation strength depending on bone mineral density.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Primary screw perforation or subsequent screw cut-out following proximal humerus fracture fixation using locking plates: a review of causative factors and proposed solutions.International orthopaedics · 2018Review
- Juvenile bovine bone is an appropriate surrogate for normal and reduced density human bone in biomechanical testing: a validation study.Scientific reports · 2018Article
- Radiographic predictors for bone mineral loss: Cortical thickness and index of the distal femur.Bone & joint research · 2018Article
- Risk Factors for Neck Shortening in Patients with Valgus Impacted Femoral Neck Fractures Treated with Three Parallel Screws: Is Bone Density an Affecting Factor?Hip & pelvis · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe goal of our systematic literature search was to prove whether the experimentally shown influence of osteoporosis on fracture fixation could be confirmed in clinical studies. Despite significant effects in several studies, this is not supported by pooled data due to lack of accurate osteoporosis assessment and complication definitions.
introductionThe fact that osteoporosis causes fractures is well-known; the assumption that it aggravates their orthopaedic treatment has not been proven. The goal of our systematic literature search was to find out whether the experimentally proven influence of osteoporosis on fracture fixation could be confirmed in clinical studies.
methodsA systematic electronic database search was performed identifying articles that evaluated complications after fracture fixation among patients suspected of having osteoporosis as measured by BMD or surrogates including Singh index or risk factors. To determine complications risks (relative risk within 95% confidence interval) data were pooled across studies, weighted by sample size and stratified by treatment type.
resultsTen studies out of 77 randomized controlled trials (51 hip, 23 distal radius and three proximal humerus studies) and three systematic reviews finally met eligibility criteria. Despite significant differences of the relative complication risk between osteoporotic and non-osteoporotic patients in several studies, this could not be proven in the pooled data.
conclusionsIn contrast to biomechanical evidence that local osteoporosis affects anchorage of implants, this could not be reproduced in clinical studies, due to the lack of accurate osteoporosis assessment, missing complication definitions and heterogeneous inclusion criteria in these studies. Prospective studies are required that address specifically the correlation between local bone status and the risk of fixation failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.