ArticleMolecular and cellular biochemistry2008
Epicatechin gallate increases glutamate uptake and S100B secretion in C6 cell lineage.
Article in Molecular and cellular biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Catechins in stroke: multi-target mechanisms, preclinical evidence, and translational challenges.Frontiers in pharmacology · 2026Review
- Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses.Biomolecules · 2024Review
- Plant Extract ofAntioxidants (Basel, Switzerland) · 2021Article
- Potential Glioprotective Strategies Against Diabetes-Induced Brain Toxicity.Neurotoxicity research · 2021Review
- Dietary Polyphenols in the Prevention of Stroke.Oxidative medicine and cellular longevity · 2017Review
- Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease.Current medicinal chemistry · 2016Review
- Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells.Molecules (Basel, Switzerland) · 2015Review
- Cellular senescence induced by prolonged subculture adversely affects glutamate uptake in C6 lineage.Neurochemical research · 2014Article
- High-glucose and S100B stimulate glutamate uptake in C6 glioma cells.Neurochemical research · 2012Article
- The S100B/RAGE Axis in Alzheimer's Disease.Cardiovascular psychiatry and neurology · 2010Article
- Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons.Cellular and molecular neurobiology · 2009Article
- Natural polyphenols: Influence on membrane transporters.Journal of intercultural ethnopharmacologyReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a current interest in dietary compounds, such as green tea polyphenols, that can favor protection against a variety of brain disorders, including Alzheimer's disease, ischemia, and stroke. The objective of the present study was to investigate the effects of (-)-epicatechin-3-gallate (ECG), one of three three major green tea antioxidants, on C6 lineage cells. Here, we evaluated cell morphology and integrity and specific astrocyte activities; glutamate uptake and secretion of S100B in the presence of 0.1, 1 and 10 microM ECG. During 6 h of incubation, cell morphology was altered only at 10 microM ECG; however, after 24 h of treatment, cells become stellate in the presence of all concentrations of ECG. Loss of cell integrity was observed after 24 h with 10 microM ECG and represented only 6% of cells, in contrast with 2% observed at basal conditions. ECG (1-10 microM) induced a decrease (about 36%) in glutamate uptake after 1 h of incubation. After 6 h, an opposite effect occurred and ECG induced a sustained increase in glutamate uptake of about 70% from 0.1 microM. In addition, a significant increase in S100B was observed at 1 microM ECG (36%) and 10 microM ECG (69%) after 1 h, in contrast to 6 h of treatment, where all doses of ECG induced a significant increase (about 60%) in S100B secretion. These data demonstrate that ECG induces a significant improvement in glutamate uptake and S100B secretion in C6 cells, indicating that ECG could contribute to the neuroprotective role of astroglial cells.
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