ArticleWorld journal of surgery2008
Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease.
Article in World journal of surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Trial
- Reoperations for cage removal or replacement in patients undergoing ALIF: operative morbidity and surgical strategy.Neurosurgical review · 2025Observational
- Observational
- Post-Operative Adhesions: A Comprehensive Review of Mechanisms.Biomedicines · 2021Review
- Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies.Biomolecules · 2021Review
- Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms.Biomolecules · 2021Review
- Effect of platelet-rich plasma on postoperative peritoneal inflammation and adhesions.Archives of medical science : AMS · 2021Article
- A review of physiological and cellular mechanisms underlying fibrotic postoperative adhesion.International journal of biological sciences · 2021Review
- Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix.PloS one · 2019Article
- Paeoniflorin prevents postoperative peritoneal adhesion formation in an experimental rat model.Oncotarget · 2017Article
- Pseudane-VII Isolated from Pseudoalteromonas sp. M2 Ameliorates LPS-Induced Inflammatory Response In Vitro and In Vivo.Marine drugs · 2017Article
- Influence of CD68+ macrophages and neutrophils on anastomotic healing following laparoscopic sigmoid resection due to diverticulitis.International journal of colorectal disease · 2014Article
- The role of heredity in pterygium development.International journal of ophthalmology · 2014Review
- Influence of 4% icodextrin solution on peritoneal tissue response and adhesion formation.BMC surgery · 2013Article
- Chronic inflammatory cells and damaged limbal cells in pterygium.African health sciences · 2013Article
- Biocompatibility of prosthetic meshes in abdominal surgery.Seminars in immunopathology · 2011Review
- Chronological evaluation of inflammatory mediators during peritoneal adhesion formation using a rat model.Langenbeck's archives of surgery · 2011Article
- Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models.Langenbeck's archives of surgery · 2011Article
- Practical limitations of bioresorbable membranes in the prevention of intra-abdominal adhesions.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Biocompatibility and adhesion formation of different endoloop ligatures in securing the base of the appendix.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeritoneal adhesions are common and lead to significant clinical morbidity and mortality. Besides various individual factors, notably the inflammatory response to peritoneal defects affects adhesion formation. The aim of this study was to investigate whether there is inflammatory activity even in persistent adhesions.
methodsTissue specimens of 40 patients suffering peritoneal adhesions were prospectively collected. Expression profiles of seven parameters as potential mediators in cellular immune response, cell differentiation, and wound healing were analyzed (macrophages [CD68], B-lymphocytes [CD20] and T-lymphocytes [CD45], cyclo-oxygenase-2 [COX-2], Notch-3, beta-catenin, and c-myc). Furthermore, clinical details and co-morbidities were recorded.
resultsInfiltrates of mononuclear round cells were found in all adhesion specimens irrespective of the maturity. Immunohistochemical analysis identified mononuclear round cells as macrophages (CD68) and as T-lymphocytes (CD45). Expression of CD68 was significantly elevated in adhesion tissue with an age<12 months. Positive expression of CD45, COX-2, Notch-3, beta-catenin, and c-myc, was observed even in long-lasting adhesions.
conclusionsA persistent inflammatory process has to be considered, even in mature adhesions. Macrophages may play an important role in triggering adhesions, whereas T-cells and the Notch-3/beta-catenin complex signaling pathway may play a crucial role in maintaining adhesions. These findings indicate that adhesions should not be regarded simply as an adynamic result of an operative trauma but rather may be grasped as a permanent process in remodeled tissue.
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Registered trials
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