ArticleVirchows Archiv : an international journal of pathology2008
C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma.
Article in Virchows Archiv : an international journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.
- Frequency of mutations in BRAF, NRAS, and KIT in different populations and histological subtypes of melanoma: a systemic review.Melanoma research · 2020Pooled it
- Stemness and Survival: CD117Cells · 2026Article
- Electrochemotherapy as adjuvant treatment in a sinonasal mucosal melanoma in elderly patient: a case report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.Histopathology · 2023Article
- The contemporary management of cancers of the sinonasal tract in adults.CA: a cancer journal for clinicians · 2023Review
- Amelanotic melanoma of the palate: report of a case.BMJ case reports · 2022Article
- Melanoma therapeutics: a literature review.Journal of biomedical research · 2022Article
- Characterization of genetics in patients with mucosal melanoma treated with immune checkpoint blockade.Cancer medicine · 2021Article
- Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy.Frontiers in oncology · 2021Review
- Article
- Melanoma Risk and Melanocyte Biology.Acta dermato-venereologica · 2020Review
- The mutational landscape of mucosal melanoma.Seminars in cancer biology · 2020Review
- Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population.BioMed research international · 2020Article
- Article
- Analysis of KIT gene mutations in patients with melanoma of the head and neck mucosa: a retrospective clinical report.Oncotarget · 2018Article
- Strengths and Weaknesses of Pre-Clinical Models for Human Melanoma Treatment: Dawn of Dogs' Revolution for Immunotherapy.International journal of molecular sciences · 2018Review
- Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations.Oncotarget · 2017Article
- Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival.Balkan medical journal · 2017Article
- Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Mucosal Melanomas.Head and neck pathology · 2017Article
- A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma.TheScientificWorldJournal · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-kit is a trans-membrane receptor tyrosine kinase (RTK) encoded by the proto-oncogene KIT located at 4q11-12. Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. C-kit also participates in melanocyte development; hence, its involvement in oral mucosal melanoma (OMM) tumorigenesis was investigated. Immunohistochemistry and mutation analysis were performed using 18 cases of human primary OMM. Results revealed 16 cases positive to c-kit protein. Atypical melanocytes expressed c-kit. All in situ components expressed c-kit, but only four cases exhibited intense expression in the invasive component. Missense mutations were observed in four cases, and two of those correlated with increased protein expression. C-kit expression in atypical melanocytes suggests the role of c-kit in the early stage of OMM tumorigenesis. C-kit protein expression correlated with activating mutations indicating the pertinent role of the proto-oncogene KIT in the tumorigenesis of OMM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.