ArticleApplied and environmental microbiology2008
New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 84 citations in OpenAlex.
- Integrated omic analysis of a new flavor yeast strain in fermented rice milk.FEMS yeast research · 2025Article
- Exogenous Trehalose AssistsJournal of fungi (Basel, Switzerland) · 2024Article
- Evaluating cellular roles and phenotypes associated with trehalose degradation genes in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2024Article
- The Enigma ofMicroorganisms · 2024Article
- High Glucose Is a Stimulation Signal of the Salt-Tolerant YeastJournal of fungi (Basel, Switzerland) · 2024Article
- D-xylose accelerated death of pentose metabolizing Saccharomyces cerevisiae.Biotechnology for biofuels and bioproducts · 2023Article
- Article
- Deletion of NTH1 and HSP12 increases the freeze-thaw resistance of baker's yeast in bread dough.Microbial cell factories · 2022Article
- Monitoring Intracellular Metabolite Dynamics inMetabolites · 2022Article
- Kveik Brewing Yeasts Demonstrate Wide Flexibility in Beer Fermentation Temperature Tolerance and Exhibit Enhanced Trehalose Accumulation.Frontiers in microbiology · 2022Article
- Elucidation of the Natural Function of Sophorolipids Produced byJournal of fungi (Basel, Switzerland) · 2021Article
- D-glucose overflow metabolism in an evolutionary engineered high-performance D-xylose consuming Saccharomyces cerevisiae strain.FEMS yeast research · 2021Article
- Interactive effects of polyamines and arbuscular mycorrhiza in modulating plant biomass, NEnvironmental science and pollution research international · 2020Article
- Article
- Metabolic adjustment upon repetitive substrate perturbations using dynamicMicrobial cell factories · 2017Article
- Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.Virulence · 2017Article
- Interaction of storage carbohydrates and other cyclic fluxes with central metabolism: A quantitative approach by non-stationaryMetabolic engineering communications · 2016Article
- Maintenance-energy requirements and robustness of Saccharomyces cerevisiae at aerobic near-zero specific growth rates.Microbial cell factories · 2016Article
- Improving freeze-tolerance of baker's yeast through seamless gene deletion of NTH1 and PUT1.Journal of industrial microbiology & biotechnology · 2016Article
- Accurate Measurement of the in vivo Ammonium Concentration in Saccharomyces cerevisiae.Metabolites · 2016Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In the yeast Saccharomyces cerevisiae, the synthesis of endogenous trehalose is catalyzed by a trehalose synthase complex, TPS, and its hydrolysis relies on a cytosolic/neutral trehalase encoded by NTH1. In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization. Yeast is also endowed with an acid trehalase encoded by ATH1 and an H+/trehalose transporter encoded by AGT1, which can together sustain assimilation of exogenous trehalose. We showed that a tps1 mutant defective in the TPS catalytic subunit cultivated on trehalose, or on a dual source of carbon made of galactose and trehalose, accumulated high levels of intracellular trehalose by its Agt1p-mediated transport. The accumulated disaccharide was mobilized as soon as cells entered the stationary phase by a process requiring a coupling between its export and immediate extracellular hydrolysis by Ath1p. Compared to what is seen for classical growth conditions on glucose, this mobilization was rather unique, since it took place prior to that of glycogen, which was postponed until the late stationary phase. However, when the Ath1p-dependent mobilization of trehalose identified in this study was impaired, glycogen was mobilized earlier and faster, indicating a fine-tuning control in carbon storage management during periods of carbon and energy restriction.
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