ArticleBiophysical journal2008
The dynamics of phosphodiesterase activation in rods and cones.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Emerging Therapeutic Approaches and Genetic Insights in Stargardt Disease: A Comprehensive Review.International journal of molecular sciences · 2024Review
- Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.The Journal of physiology · 2022Review
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Analysis of waveform and amplitude of mouse rod and cone flash responses.The Journal of physiology · 2021Article
- Article
- A kinetic analysis of mouse rod and cone photoreceptor responses.The Journal of physiology · 2020Article
- Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction.Molecular vision · 2016Article
- How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Detection of single photons by toad and mouse rods.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Speed, adaptation, and stability of the response to light in cone photoreceptors: the functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels.The Journal of general physiology · 2012Article
- Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod photoresponse.PLoS computational biology · 2010Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phototransduction starts with the activation of a rhodopsin (respectively, coneopsin) molecule, located in the outer segment of rod (respectively, cone) photoreceptors. The subsequent amplification pathway proceeds via the G-protein transducin to the activation of phosphodiesterase (PDE), a G-protein coupled effector enzyme. In this article, we study the dynamics of PDE activation by constructing a Markov model that is based on the underlying chemical reactions including multiple rhodopsin phosphorylations. We derive explicit equations for the mean and the variance of activated PDE. Our analysis reveals that a low rhodopsin lifetime variance is neither necessary nor sufficient to achieve reliable PDE activation. The numerical simulations show that during the rising phase the variability of PDE activation is much lower compared to the recovery phase, and this property depends crucially on the transducin activation rates. Furthermore, we find that the dynamics of the activation process greatly differs depending on whether rhodopsin or PDE deactivation limits the recovery of the photoresponse. Finally, our simulations for cones show that only very few PDEs are activated by an excited photopigment, which might explain why in S-cones no single photon response can be observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.