ArticleAIDS and behavior2008
Probability of HIV transmission during acute infection in Rakai, Uganda.
Article in AIDS and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Impact of viral load and the duration of primary infection on HIV transmission: systematic review and meta-analysis.AIDS (London, England) · 2014Pooled it
- Concurrent partnerships and HIV: an inconvenient truth.Journal of the International AIDS Society · 2011Pooled it
- Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies.The Lancet. Infectious diseases · 2009Pooled it
- Understanding of Perceived Infectiousness and Its Influence on Sexual Behavior Among Individuals With Acute HIV Infection in Lilongwe, Malawi (HPTN 062).AIDS education and prevention : official publication of the International Society for AIDS Education · 2020Trial
- HIV-related stigma and universal testing and treatment for HIV prevention and care: design of an implementation science evaluation nested in the HPTN 071 (PopART) cluster-randomized trial in Zambia and South Africa.Health policy and planning · 2016Trial
- Recent HIV infection among women and men enrolling to care in urban clinics in Ethiopia.BMC infectious diseases · 2026Article
- A potential transition from a concentrated to a generalized HIV epidemic: the case of Madagascar.Infectious diseases of poverty · 2023Article
- Projected Life Expectancy Gains From Improvements in HIV Care in Black and White Men Who Have Sex With Men.JAMA network open · 2023Article
- Viral suppression among pregnant adolescents and women living with HIV in rural KwaZulu-Natal, South Africa: a cross sectional study to assess progress towards UNAIDS indicators and Implications for HIV Epidemic Control.Reproductive health · 2022Article
- The impact of condom use on the HIV epidemic.Gates open research · 2021Article
- Improving HIV outreach testing yield at cross-border venues in East Africa.AIDS (London, England) · 2020Article
- Mathematical Modelling of HIV-HCV Coinfection Dynamics in Absence of Therapy.Computational and mathematical methods in medicine · 2020Article
- Weighing the Evidence of Efficacy of Oral PrEP for HIV Prevention in Women in Southern Africa.AIDS research and human retroviruses · 2018Review
- Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition.PLoS computational biology · 2018Article
- Use of routine HIV testing data for early detection of emerging HIV epidemics in high-risk subpopulations: A concept demonstration study.Infectious Disease Modelling · 2018Article
- Near Full-length Genomic Sequencing and Molecular Analysis of HIV-Infected Individuals in a Network-based Intervention (TRIP) in Athens, Greece: Evidence that Transmissions Occur More Frequently from those with High HIV-RNA.Current HIV research · 2018Article
- Higher prevalence of viral control in HIV-1-infected women in serodiscordant relationships.PloS one · 2018Article
- Sensitivity of joint contagiousness and susceptibility-based dynamic optimal control strategies for HIV prevention.PloS one · 2018Article
- A rapid ultrasound particle agglutination method for HIV antibody detection: Comparison with conventional rapid HIV tests.Journal of virological methods · 2017Article
- Sexual network drivers of HIV and herpes simplex virus type 2 transmission.AIDS (London, England) · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Accurate estimates of the probability of HIV transmission during various stages of infection are needed to inform epidemiological models. Very limited information is available about the probability of transmission during acute HIV infection. We conducted a secondary analysis of published data from the Rakai, Uganda seroconversion study. Mathematical and computer-based models were used to quantify the per-act and per-partnership transmission probabilities during acute and chronic HIV infection, and to estimate how many of the transmission events reported in the Rakai study were due to acute-phase HIV transmission. The average per-act transmission probability during acute infection equaled 0.03604 vs. 0.00084 for chronic HIV infection. Overall, HIV was transmitted during acute infection in 46.5% of 23 "incident index partner couples." Acute-phase transmission accounted for 89.1% of all transmission events in the first 20 months of follow-up. These results highlight the substantial risk of transmission during acute HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.