SynthesisStroke2008
Association between apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke.
Synthesis in Stroke, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration.European journal of preventive cardiology · 2016Pooled it
- Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.International journal of epidemiology · 2013Pooled it
- Effect of ApoE4 Genotype on the Association Between Metabolic Phenotype and Subclinical Atherosclerosis in Postmenopausal Women.The American journal of cardiology · 2019Trial
- The hypoperfusion intensity ratio associates with APOE gene polymorphism in acute ischemic stroke patients with large vessel occlusion.Scientific reports · 2025Article
- A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers.Alzheimer's research & therapy · 2025Article
- Extracranial carotid artery atherosclerotic plaque and APOE polymorphisms: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Article
- Cardiorespiratory fitness decreases the odds for subclinical carotid plaques in apolipoprotein e4 homozygotes.Scientific reports · 2022Article
- Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke.Scientific reports · 2022Article
- Serum Biomarkers in Carotid Artery Disease.Diagnostics (Basel, Switzerland) · 2021Review
- Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2021Article
- Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort.JAMA neurology · 2020Article
- Interaction betweenAlzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Apolipoprotein E Gene Polymorphism and Subclinical Carotid Atherosclerosis: The Northern Manhattan Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
- Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.Bioscience reports · 2017Article
- Role of apolipoprotein E in neurodegenerative diseases.Neuropsychiatric disease and treatment · 2015Review
- Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults.Journal of the American Geriatrics Society · 2013Article
- Does Apolipoprotein E genotype affect cardiovascular risk in subjects with acromegaly?Endocrine · 2012Article
- Gender-dependent correlations of carotid intima-media thickness with gene expression in blood.Translational stroke research · 2011Article
- Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study.Journal of epidemiology and community health · 2010Article
- Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.Lipids in health and disease · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeApolipoprotein E genotype (APOE) influences cholesterol levels and ischemic heart disease. Although there is no convincing overall association with ischemic stroke, APOE may influence large artery (atherothrombotic) stroke, for which carotid intima-media thickness (CIMT) is an informative intermediate phenotype. We therefore performed a systematic review and meta-analysis of the association between APOE and CIMT.
methodsWe sought all published studies assessing the association between APOE and CIMT. From each study, we extracted available data on study methods, subjects' characteristics, and mean (and standard deviation) CIMT for each genotype or genotype group. We calculated study-specific and random effects pooled differences in mean CIMT between genotype groups, and assessed heterogeneity between studies and predefined subgroups using I(2) and chi(2) statistics.
resultsMeta-analysis of 22 published studies (30,879 subjects) showed a significant association between APOE and CIMT (pooled mean difference epsilon 4- versus epsilon 2-allele containing genotypes 46 microm, 95% CI 29 to 62, P<0.00001). We found evidence of small study (mainly publication) bias, with a diminished (but still highly statistically significant) association in studies of >1000 subjects (pooled mean difference 17 microm, 95% CI 12 to 23, P<0.00001). The association was larger among high vascular risk and eastern Asian populations, but this may simply reflect the smaller size of these studies.
conclusionsOur results show a clear association of APOE with CIMT, even though publication bias means that this is overestimated by the published literature. These findings suggest the possibility of a specific association with large artery ischemic stroke.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.