ReviewJournal of applied physiology (Bethesda, Md. : 1985)2008
Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
162 citing papers in PubMed, 4 syntheses or guidelines pooled it, 320 citations in OpenAlex.
- Systematic review and meta-analysis of the effectiveness of rehabilitation interventions on upper limb function in patients with systemic sclerosis.Frontiers in medicine · 2026Pooled it
- Effects of different exercise modes on the risk factors of arteriosclerosis in postmenopausal women: A systematic review and network meta-analysis.Journal of human hypertension · 2025Pooled it
- Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Effective of high-intensity interval training and moderate-intensity continuous training on body composition, glycolipid metabolism, and cardiopulmonary function in patients with pre-diabetes: a randomized controlled trial.Frontiers in endocrinology · 2025Trial
- Stent edge vascular response and in-stent geometry after aerobic exercise.Cardiovascular intervention and therapeutics · 2021Trial
- Modulation of Endothelial Glycocalyx and Microcirculation in Healthy Young Men during High-Intensity Sprint Interval Cycling-Exercise by Supplementation with Pomegranate Extract. A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study.Vascular health and risk management · 2020Trial
- The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients.Arthritis research & therapy · 2018Trial
- UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Circuit resistance training attenuates acute exertion-induced reductions in arterial function but not inflammation in obese women.Metabolic syndrome and related disorders · 2015Trial
- Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation.The Journal of physiology · 2014Trial
- Sprint interval and sprint continuous training increases circulating CD34+ cells and cardio-respiratory fitness in young healthy women.PloS one · 2014Trial
- Unlocking the barriers to improved functional capacity in the elderly: rationale and design for the "Fit for Life trial".Contemporary clinical trials · 2013Trial
- Brachial artery flow-mediated dilation following exercise with augmented oscillatory and retrograde shear rate.Cardiovascular ultrasound · 2012Trial
- Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise.Physiological genomics · 2011Trial
- Impact of chronic intermittent external compressions on forearm blood flow capacity in humans.European journal of applied physiology · 2011Trial
- Rapid vascular modifications to localized rhythmic handgrip training and detraining: vascular conditioning and deconditioning.European journal of applied physiology · 2010Trial
- Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.American journal of physiology. Heart and circulatory physiology · 2010Trial
- Resting arterial diameter and blood flow changes with resistance training and detraining in healthy young individuals.Journal of athletic trainingTrial
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Current evidence indicates that the ability of physical activity to sustain a normal phenotype of arterial endothelial cells (ECs) plays a central role in the beneficial effects of exercise (Ex) on atherosclerotic disease. Here we evaluate the strength of evidence that shear stress (SS) and/or circumferential wall stress (stretch) are the primary signals, produced by bouts of Ex, that signal altered gene expression in arterial ECs, thereby resulting in a less atherogenic EC phenotype. Current literature indicates that SS is a signal for expression of antiatherogenic genes in cultured ECs, in ECs of isolated arteries, and in ECs of arteries in intact animals. Furthermore, SS levels in the arteries of humans during Ex are in the range that produces beneficial changes. In contrast, complex flow profiles within recirculation zones and/or oscillatory flow patterns can cause proatherogenic gene expression in ECs. In vivo evidence indicates that Ex decreases oscillatory flow/SS in some portions of the arterial tree but may increase oscillatory flow in other areas of the arterial tree. Circumferential wall stress can increase expression of some beneficial EC genes as well, but circumferential wall stress also increases production of reactive oxygen species and increases the expression of adhesion factors and other proatherogenic genes. Interactions of arterial pressure and fluid SS play an important role in arterial vascular health and likely contribute to how Ex bouts signal changes in EC gene expression. It is also clear that other local and circulating factors interact with these hemodynamic signals during Ex to produce the healthy arterial EC phenotype. We conclude that available evidence suggests that exercise signals formation of beneficial endothelial cell phenotype at least in part through changes in SS and wall stretch in the arteries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.