Evidence map›Paper›PMID 18063722›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2007

Interspecies interactions within oral microbial communities.

Howard K Kuramitsu, Xuesong He, Renate Lux, Maxwell H Anderson, Wenyuan Shi

Open access · hybridAbstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
256citing papers in PubMed, 1 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

256 citing papers in PubMed, 1 synthesis or guideline pooled it, 596 citations in OpenAlex.

  1. Pooled it
  2. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash ContainingInternational journal of environmental research and public health · 2021
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196 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Howard K KuramitsuDepartment of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA.
Xuesong He
Renate Lux
Maxwell H Anderson
Wenyuan Shi
University of California, Los Angeles · USC3J Therapeutics (United States) · USUniversity at Buffalo, State University of New York · US

Funding

INTERCELLULAR SIGNALING IN MYXOCOCCUS XANTHUSR01GM054666 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHI, WENYUAN · 1996 to 2010
$3.1M
MOLECULAR GENETIC ANALYSIS OF S MUTANS CARIOGENICITYR01DE003258 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SHARMA, ASHU · 1985 to 2004
$1.1M
ORAL SPIROCHETES--MOLECULAR GENETICS ANALYSISR01DE009821 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI SHARMA, ASHU · 1992 to 2004
$1.0M
Targeted antimicrobial therapy for dental cariesR42MD001831 · NIMHD · C3 JIAN, LLC · PI ANDERSON, MAXWELL H, SHI, WENYUAN · 2007 to 2008
$1.0M
Targeted Antimicrobial Therapy for Dental CariesR41MD001831 · NIMHD · C3 JIAN, INC. · PI ANDERSON, MAXWELL H · 2005 to 2005
$100k
MOLECULAR GENETIC ANALYSIS OF S. MUTANS CARIOGENICITYR37DE003258 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI KURAMITSU, HOWARD K · 1986 to 1995
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NIDCR NIH HHS DE03258NIDCR NIH HHS DE09821NIDCR NIH HHS R01 DE003258NIDCR NIH HHS R01 DE009821NIGMS NIH HHS GM54666NIGMS NIH HHS R01 GM054666NIMHD NIH HHS MD01831NIMHD NIH HHS R41 MD001831NIMHD NIH HHS R42 MD001831
6 · The paper itself

Abstract

While reductionism has greatly advanced microbiology in the past 400 years, assembly of smaller pieces just could not explain the whole! Modern microbiologists are learning "system thinking" and "holism." Such an approach is changing our understanding of microbial physiology and our ability to diagnose/treat microbial infections. This review uses oral microbial communities as a focal point to describe this new trend. With the common name "dental plaque," oral microbial communities are some of the most complex microbial floras in the human body, consisting of more than 700 different bacterial species. For a very long time, oral microbiologists endeavored to use reductionism to identify the key genes or key pathogens responsible for oral microbial pathogenesis. The limitations of reductionism forced scientists to begin adopting new strategies using emerging concepts such as interspecies interaction, microbial community, biofilms, polymicrobial disease, etc. These new research directions indicate that the whole is much more than the simple sum of its parts, since the interactions between different parts resulted in many new physiological functions which cannot be observed with individual components. This review describes some of these interesting interspecies-interaction scenarios.

Indexed as

Bacterial Physiological PhenomenaBacteriaBiofilmsDental PlaqueGenome, BacterialHumansMouthPeriodontal DiseasesPolymerase Chain ReactionResearchVirulence

Identifiers

PMID18063722
PMCPMC2168648
OpenAlexW2096008023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.