ArticleThe American journal of pathology2008
Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- C-reactive protein: a target for therapy to reduce inflammation.Frontiers in immunology · 2023Review
- Identification of key differential genes in intimal hyperplasia induced by left carotid artery ligation.PeerJ · 2022Article
- The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells.Mediators of inflammation · 2021Article
- Recent advances into the role of pattern recognition receptors in transplantation.Cellular immunology · 2020Review
- Therapeutic Lowering of C-Reactive Protein.Frontiers in immunology · 2020Review
- Diagnosis and Management of Cardiovascular Disease in Advanced and End-Stage Renal Disease.Journal of the American Heart Association · 2016Review
- Estrogen and Cardiovascular Disease: Is Timing Everything?The American journal of the medical sciences · 2015Review
- Fcγ receptors and ligands and cardiovascular disease.Circulation research · 2015Review
- C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts.Journal of thrombosis and haemostasis : JTH · 2014Article
- Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- C-reactive protein and hypertension.Journal of human hypertension · 2014Review
- Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.Mediators of inflammation · 2014Article
- Effects of antisense oligonucleotides against C-reactive protein on the development of atherosclerosis in WHHL rabbits.Mediators of inflammation · 2014Article
- Pentraxins: structure, function, and role in inflammation.ISRN inflammation · 2013Review
- Inflammatory markers are associated with left ventricular hypertrophy and diastolic dysfunction in a population-based sample of elderly men and women.Journal of human hypertension · 2013Article
- Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury.Circulation · 2012Article
- Coupling of Fcγ receptor I to Fcγ receptor IIb by SRC kinase mediates C-reactive protein impairment of endothelial function.Circulation research · 2011Article
- Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages.Microbiology (Reading, England) · 2011Article
- Effects of human C-reactive protein on pathogenesis of features of the metabolic syndrome.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors.Current opinion in organ transplantation · 2011Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Neointima formation after vascular injury is exaggerated in ovariectomized (OVX) human C-reactive protein transgenic mice (CRPtg) compared to nontransgenic mice (NTG). We tested the hypothesis that this CRP-mediated exacerbation requires IgG Fc receptors (Fc gamma Rs). OVX NTG, CRPtg, and CRPtg lacking Fc gamma RI, Fc gamma RIIb, Fc gamma RIII, or the common gamma chain (FcR gamma) had their common carotid artery ligated. Twenty-eight days later neointimal thickening in CRPtg/Fc gamma RI(-/-) and CRPtg/FcR gamma (-/-) was significantly less than in CRPtg and no worse than in NTG, whereas in CRPtg/Fc gamma RIIb(-/-) and CRPtg/Fc gamma RIII(-/-) neointimal thickness was equal to or greater than in CRPtg. Immunohistochemistry revealed human CRP in the neointima of CRPtg, but little or none was observed in those lacking Fc gamma RI or FcR gamma. Real-time reverse transcriptase-polymerase chain reaction demonstrated that Fc gamma R types I to III were expressed in the CRPtg arteries, with Fc gamma RI expression increasing by threefold after ligation injury. Levels of serum complement (C3), neointimal deposition of complement (C3d), and cellular composition (monocytes, macrophages, lymphocytes) in the neointima did not differ among the different CRPtg genotypes. However, by immunofluorescence a neointimal population of F4/80+CRP+ cells was revealed only in OVX CRPtg. The exaggerated response to vascular injury provoked by CRP in OVX CRPtg depends on Fc gamma RI and probably requires its expression by F4/80+ cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.