ArticleFungal genetics and biology : FG & B2008
Mating is rare within as well as between clades of the human pathogen Candida albicans.
Article in Fungal genetics and biology : FG & B, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.PLoS pathogens · 2024Article
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Significant variation of filamentation phenotypes in clinicalFrontiers in cellular and infection microbiology · 2023Article
- Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.Cell host & microbe · 2021Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Phased Diploid Genome Assemblies for Three Strains ofG3 (Bethesda, Md.) · 2019Article
- Diverse Lineages ofGenetics · 2019Article
- The Genome of the Human PathogenmBio · 2018Article
- Gene flow contributes to diversification of the major fungal pathogen Candida albicans.Nature communications · 2018Article
- Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans.Pathogens (Basel, Switzerland) · 2018Review
- The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity.Mucosal immunology · 2017Article
- Candida albicans cell-type switching and functional plasticity in the mammalian host.Nature reviews. Microbiology · 2017Review
- Ploidy dynamics and evolvability in fungi.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Article
- Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans.Current genetics · 2016Review
- The parasexual lifestyle of Candida albicans.Current opinion in microbiology · 2015Review
- Article
- Parasexual Ploidy Reduction Drives Population Heterogeneity Through Random and Transient Aneuploidy in Candida albicans.Genetics · 2015Article
- The spectrum of fungi that infects humans.Cold Spring Harbor perspectives in medicine · 2014Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Candida albicans is a diploid yeast that can undergo mating and a parasexual cycle, but is apparently unable to undergo meiosis. Characterization of the population structure of C. albicans has shown that reproduction is largely clonal and that mating, if it occurs, is rare or limited to genetically related isolates. Because molecular typing has delineated distinct clades in C. albicans, we have tested whether recombination was common within clades, but rare between clades. Two hundred and three C. albicans isolates have been subjected to multilocus sequence typing (MLST) and the haplotypes at heterozygous MLST genotypes characterized. The C. albicans isolates were distributed among nine clades, of which five corresponded to those previously identified by Ca3 fingerprinting. In each of these clades with more than 10 isolates, polymorphic nucleotide positions located on between 3 and 4 of the six loci were in Hardy-Weinberg disequilibrium. Moreover, each of these polymorphic sites contained excess heterozygotes. This was confirmed by an expanded analysis performed on a recently published MLST dataset for 1044 isolates. On average, 66% of polymorphic positions in the individual clades were in significant excess of heterozygotes over the five clades. These data indicate that mating within clades as well as self-fertilization are both limited and that C. albicans clades do not represent a collection of cryptic species. The study of haplotypes at heterozygous loci performed on our dataset indicates that loss of heterozygosity events due to mitotic recombination is moderately common in natural populations of C. albicans. The maintenance of substantial heterozygosity despite relatively frequent loss of heterozygosity could result from a selective advantage conferred by heterozygosity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.