Evidence map›Paper›PMID 18061977›Full record

ArticleThe Journal of rheumatology2008

Trends in drug prescribing for osteoporosis after hip fracture, 1995-2004.

Suzanne M Cadarette, Jeffrey N Katz, M Alan Brookhart, Raisa Levin, Margaret R Stedman, Niteesh K Choudhry, Daniel H Solomon

Abstract read
In one paragraph

Article in The Journal of rheumatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 68 citations in OpenAlex.

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  12. Use of anti-osteoporosis medication dispensing by patients with hip fracture: could we do better?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  13. Article
  14. Minodronate for the treatment of osteoporosis.Therapeutics and clinical risk management · 2018
    Review
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  16. Article
  17. Article
  18. Anti-osteoporosis drug prescribing after hip fracture in the UK: 2000-2010.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015
    Article
  19. The risk of major and any (non-hip) fragility fracture after hip fracture in the United Kingdom: 2000-2010.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014
    Article
  20. Osteoporosis medication use after hip fracture in U.S. patients between 2002 and 2011.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014
    Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Suzanne M CadaretteDivision of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA. s.cadarette@utoronto.ca
Jeffrey N Katz
M Alan Brookhart
Raisa Levin
Margaret R Stedman
Niteesh K Choudhry
Daniel H Solomon
Harvard University · US

Funding

Trial of risk mangement for prevention of accelerated atherosclerosis in SLEP60AR047782 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KARLSON, ELIZABETH W · 2001 to 2016
$18.8M
Musculoskeletal Research and Mentoring ProgramsK24AR002123 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2000 to 2009
$1.1M
Hierarchical models of prescription drug use in the elderlyK25AG027400 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BROOKHART, MAURICE ALAN · 2006 to 2010
$653k
Osteoporosis in Women with Rheumatoid ArthritisR21AG027066 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SOLOMON, DANIEL HAL · 2005 to 2006
$335k
NIAMS NIH HHS K24 AR002123NIAMS NIH HHS K24 AR02123NIAMS NIH HHS P60 AR047782NIAMS NIH HHS P60 AR47782NIA NIH HHS K25 AG027400NIA NIH HHS R21 AG027066
6 · The paper itself

Abstract

objectiveTo examine trends in osteoporosis drug prescribing after hip fracture from 1995 to 2004.

methodsWe conducted a population-based study of enrollees in the Pennsylvania Pharmaceutical Assistance Contract for the Elderly. Hip fractures were identified using Medicare hospital claims between January 1, 1995, and June 30, 2004. Osteoporosis treatment comprised oral bisphosphonates, calcitonin, hormone therapy, raloxifene, and/or teriparatide. Kaplan-Meier methods were used to estimate the probability of treatment within 6 months of fracture, censoring patients on their date of death or 6 months postfracture.

resultsTreatment within 6 months after hip fracture improved from 7% in 1995 to 31% in 2002, and then remained stable through 2004. Similar patterns were observed among new users, with treatment increasing from 4% in 1995 to 17% in 2002, with no subsequent increase through 2004. Bisphosphonates led other treatments in the frequency of prescribing, except during 1997-99, when calcitonin was the most common. Among women, hormone therapy prescribing decreased from 22% of those treated in 1995 to 4% in 2004, and raloxifene prescribing remained relatively constant (4%-10%) since its introduction (p for trend = 0.15). Of patients treated before and after hip fracture, 18% changed therapy postfracture. Significantly more patients changed therapy following fracture if a different physician prescribed treatment (26%) compared to those treated by the same physician pre- and postfracture (13%; p < 0.0001).

conclusionPrescribing practices changed substantially over the 10 years of study. The proportion of hip fracture patients treated with osteoporosis drugs has increased, but remains low, with fewer than one-third receiving pharmacotherapy.

Indexed as

AgedAged, 80 and overBone Density Conservation AgentsFemaleHip FracturesHumansLongitudinal StudiesMaleOsteoporosisPennsylvaniaPractice Patterns, Physicians'Retrospective StudiesBone Density Conservation Agents

Identifiers

PMID18061977
PMCPMC3256248
OpenAlexW1943094800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.