ReviewSeminars in nephrology2007
Proteomics for biomarker discovery in acute kidney injury.
Review in Seminars in nephrology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- The clinical efficacy of cGMP-specific sildenafil on mitochondrial biogenesis induction and renal damage in cats with acute on chronic kidney disease.BMC veterinary research · 2024Article
- Machine learning based biomarker discovery for chronic kidney disease-mineral and bone disorder (CKD-MBD).BMC medical informatics and decision making · 2024Article
- Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions.Frontiers in pharmacology · 2024Review
- Review
- Evaluation of renal function in rats with moderate and mild brain trauma.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases.Biomolecules · 2021Review
- Contribution of Predictive and Prognostic Biomarkers to Clinical Research on Chronic Kidney Disease.International journal of molecular sciences · 2020Review
- The NETest liquid biopsy is diagnostic for gastric neuroendocrine tumors: observations on the blood-based identification of microscopic and macroscopic residual diseaseOK.BMC gastroenterology · 2020Article
- Current Status of Novel Biomarkers for the Diagnosis of Acute Kidney Injury: A Historical Perspective.Journal of intensive care medicine · 2020Article
- Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study.Annals of intensive care · 2017Article
- Urinary metabolites in patients undergoing coronary catheterization via the radial versus femoral artery approach.Proceedings (Baylor University. Medical Center) · 2017Article
- Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging.American journal of physiology. Renal physiology · 2016Article
- Biomarkers for childhood-onset systemic lupus erythematosus.Current rheumatology reports · 2015Review
- Biomarkers and updates on pediatrics lupus nephritis.Rheumatic diseases clinics of North America · 2013Review
- Proteomics and metabolomics in renal transplantation-quo vadis?Transplant international : official journal of the European Society for Organ Transplantation · 2013Review
- Marking renal injury: can we move beyond serum creatinine?Translational research : the journal of laboratory and clinical medicine · 2012Review
- Systems biology of kidney diseases.Kidney international · 2012Review
- Acute kidney injury in childhood: should we be worried about progression to CKD?Pediatric nephrology (Berlin, Germany) · 2011Review
- Biomarkers for the early detection of acute kidney injury.Current opinion in pediatrics · 2011Review
- Biomarker discovery and development in pediatric critical care medicine.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2011Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Acute kidney injury (AKI), previously referred to as acute renal failure, represents a common and devastating problem in clinical medicine. Despite significant improvements in therapeutics, the mortality and morbidity associated with AKI remain high. A major reason for this is the lack of early markers for AKI, and hence an unacceptable delay in initiating therapy. Fortunately, the application of innovative technologies such as functional genomics and proteomics to human and animal models of AKI has uncovered several novel biomarkers and therapeutic targets. The most promising of these are chronicled in this review. These include the identification of biomarker panels in plasma (neutrophil gelatinase-associated lipocalin and cystatin C) and urine (neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, interleukin-18, cystatin C, alpha1-microglobulin, Fetuin-A, Gro-alpha, and meprin). It is likely that the AKI panels will be useful for timing the initial insult, and assessing the duration and severity of AKI. It is also probable that the AKI panels will distinguish between the various etiologies of AKI and predict clinical outcomes. It will be important in future studies to validate the sensitivity and specificity of these biomarker panels in clinical samples from large cohorts and from multiple clinical situations. Such studies will be facilitated markedly by the development of commercial tools for the reproducible measurement of biomarkers across different laboratories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.