ArticleMechanisms of ageing and development
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity.
Article in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity.International journal of molecular sciences · 2021Article
- Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus.Laboratory animal research · 2019Article
- Review
- Relevance of the p53-MDM2 axis to aging.Cell death and differentiation · 2018Review
- Dysfunction of the MDM2/p53 axis is linked to premature aging.The Journal of clinical investigation · 2017Article
- No Evaluation of Serum P53 Levels in Iraqi Female Breast Cancer PatientsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Do p53 stress responses impact organismal aging?Translational cancer research · 2016Article
- p53 as an intervention target for cancer and aging.Pathobiology of aging & age related diseases · 2013Review
- Senescence regulation by the p53 protein family.Methods in molecular biology (Clifton, N.J.) · 2013Review
- mTORC1 and p53: clash of the gods?Cell cycle (Georgetown, Tex.) · 2013Article
- Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor.Oncotarget · 2011Review
- Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38MAPK/CK2 signaling in human breast cancer cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- The Regulation of Aging and Longevity: A New and Complex Role of p53.Genes & cancer · 2011Article
- Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.Experimental gerontology · 2010Article
- Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.Cancer immunology, immunotherapy : CII · 2009Review
- Using mice to examine p53 functions in cancer, aging, and longevity.Cold Spring Harbor perspectives in biology · 2009Review
- Article
- Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging.Mechanisms of ageing and development · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Evidence has accumulated that p53, a prototypical tumor suppressor, may also influence aspects of organismal aging. We have previously described a p53 mutant mouse model, the p53+/m mouse, which is cancer resistant yet exhibits reduced longevity and premature aging phenotypes. p53+/m mice express one full length p53 allele and one truncated p53 allele that is translated into a C-terminal fragment of p53 termed the M protein. The augmented cancer resistance and premature aging phenotypes in the p53+/m mice are consistent with a hyperactive p53 state. To determine how the M protein could increase p53 activity, we examined the M protein in various cellular contexts. Here, we show that embryo fibroblasts from p53+/m mice exhibit reduced proliferation and cell cycle progression compared to embryo fibroblasts from p53+/- mice (with equivalent wild-type p53 dosage). The M protein interacts with wild-type p53, increases its stability, and facilitates its nuclear localization in the absence of stress. Despite increasing p53 stability, the M protein does not disrupt p53-Mdm2 interactions and does not prevent p53 ubiquitination. These results suggest molecular mechanisms by which the M protein could influence the aging and cancer resistance phenotypes in the p53+/m mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.