Evidence map›Paper›PMID 18060669›Full record

ArticleClinical biomechanics (Bristol, Avon)2008

Examining outcomes from total knee arthroplasty and the relationship between quadriceps strength and knee function over time.

Yuri Yoshida, Ryan L Mizner, Dan K Ramsey, Lynn Snyder-Mackler

Registry-linked trialAbstract read
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03421938 (Investigation of the Effect of Downhill-uphill Walking Exercises on Functional Level and Muscle Strength in Patients With Knee Arthroplasty.), which is not on this map. Cited by 117 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03421938 nawithdrawnnot on this mapstarted 2017, after this paper: background citation

Investigation of the Effect of Downhill-uphill Walking Exercises on Functional Level and Muscle Strength in Patients With Knee Arthroplasty.

TypeinterventionalSponsorDokuz Eylul UniversityRan2017 to 2018Enrolled0ConditionsKnee ArthroplastyArmsWalking Exercise
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  3. The effect of total knee arthroplasty on patients' balance and incidence of falls: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
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  8. Gene expression analysis of vastus medialis cells after tourniquet-induced ischemia during total knee arthroplasty: a randomized clinical trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021
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  14. Effect of limited ischemia time on the amount and function of mitochondria within human skeletal muscle cells.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuri YoshidaDepartment of Physical Therapy, Graduate Program in Biomechanics and Movement Sciences, Center for Biomedical Engineering Research University of Delaware, Newark, DE 19716, USA.
Ryan L Mizner
Dan K Ramsey
Lynn Snyder-Mackler

Funding

VALGUS BRACING FOR MEDIAL LAXITY IN PATIENTS WITH OSTEOARTHRITISP20RR016458 · NCRR · UNIVERSITY OF DELAWARE · PI RUDOLPH, KATHERINE S · 2002 to 2011
$18.9M
ACL Injured Knee: MRI and Biomechanical ModelingR01AR046386 · NIAMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 1999 to 2011
$2.8M
NMES for Older Individuals After Total Knee ArthroplastyR01HD041055 · NICHD · UNIVERSITY OF DELAWARE · PI SNYDER-MACKLER, LYNN · 2002 to 2006
$1.4M
MOTION ANALYSIS SYSTEM FOR STUDY OF HUMAN MOVEMENT DYSFUNCTION: PHYSICAL THERAPYS10RR022396 · NCRR · UNIVERSITY OF DELAWARE · PI SNYDER-MACKLER, LYNN · 2006 to 2006
$222k
NCRR NIH HHS P20 RR016458NCRR NIH HHS P20RR016458NCRR NIH HHS S10 RR022396NIAMS NIH HHS R01 AR046386NICHD NIH HHS R01 HD041055NICHD NIH HHS R01HD041055
6 · The paper itself

Abstract

backgroundTemporal-spatial gait parameters improve following total knee arthroplasty (TKA) but lower limb kinematics and moments fail to match those of age-matched healthy individuals. The aim of this study was to determine whether quadriceps strength, clinical measures of knee function, lower limb kinematics, and joint moments improve following arthroplasty and normalize over time.

methodsTwelve patients underwent total knee arthroplasty were tested at 3 and 12 months following surgery. Twelve matched controls were also tested. All underwent quadriceps strength testing and gait analysis to calculate knee joint kinematics and kinetics. Function was assessed using clinical tests and self-report.

findingsAll clinical measures except for quadriceps strength significantly improved from 3 to 12 months. Gait asymmetry was observed at 3 months (lower stance times, peak knee flexion angle, range of motion and vertical ground reaction force), but ankle, knee and hip moments contributing to the total limb support moment were equivalent between legs. At 12 months, gait speed remained significantly slower than controls. Inter-limb differences in peak knee flexion angle and range of motion persisted. Greater hip and lower knee moments were evident in the operated limb, compared to the non-operated limb and controls. Quadriceps strength was positively correlated with faster times on the Time Up and Go and Stair Climbing Test and greater distances during the 6 Minute Walk test.

interpretationPatients who have undergone TKA demonstrate improvements in function as measured by self-report and functional performance measures. Gait becomes more symmetric and quadriceps strength becomes stronger. Some approached the values of healthy control subjects. Important differences still remain however. The larger hip extensor contribution to the total support moment may be to compensate for the diminished knee extensor contribution during level walking. Since instrumented gait analysis and functional performance measures appear to reflect different aspects of recovery following total knee replacement, both should be considered when evaluating gait and function.

Indexed as

Arthroplasty, Replacement, KneeGaitMuscle ContractionRange of Motion, ArticularFemaleHumansKnee JointMaleMiddle AgedMuscle, SkeletalRecovery of FunctionTreatment Outcome

Identifiers

PMID18060669
PMCPMC2293974

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.