ArticleClinical biomechanics (Bristol, Avon)2008
Examining outcomes from total knee arthroplasty and the relationship between quadriceps strength and knee function over time.
Article in Clinical biomechanics (Bristol, Avon), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03421938 (Investigation of the Effect of Downhill-uphill Walking Exercises on Functional Level and Muscle Strength in Patients With Knee Arthroplasty.), which is not on this map. Cited by 117 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effect of Downhill-uphill Walking Exercises on Functional Level and Muscle Strength in Patients With Knee Arthroplasty.
Who cites it
117 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The course of knee extensor strength after total knee arthroplasty: a systematic review with meta-analysis and -regression.Archives of orthopaedic and trauma surgery · 2023Pooled it
- Gait comparison of unicompartmental knee arthroplasty and total knee arthroplasty during level walking.PloS one · 2018Pooled it
- The effect of total knee arthroplasty on patients' balance and incidence of falls: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Pooled it
- Movement Pattern Biofeedback Training After Total Knee Arthroplasty: A Randomized Controlled Trial.Arthritis care & research · 2025Trial
- Functional Capacity at Rehabilitation Discharge Predicts Physical Activity Characteristics 24 Weeks Later for People With Total Knee Arthroplasty: A Secondary Analysis of a Randomized Controlled Trial.Archives of physical medicine and rehabilitation · 2025Trial
- Effectiveness of kinesiotaping for lymphatic drainage after bilateral total knee arthroplasty: A randomized controlled trial.Medicine · 2025Trial
- Hoffa's fat pad resection during total knee arthroplasty does not affect functioning and gait: a double-blind randomized clinical trial.Archives of orthopaedic and trauma surgery · 2024Trial
- Gene expression analysis of vastus medialis cells after tourniquet-induced ischemia during total knee arthroplasty: a randomized clinical trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Trial
- Identifying car ingress movement strategies before and after total knee replacement.International biomechanics · 2020Trial
- Restoring physical function after knee replacement: a cross sectional comparison of progressive strengthening vs standard physical therapy.Physiotherapy theory and practice · 2020Trial
- Early initiation of home-based sensori-motor training improves muscle strength, activation and size in patients after knee replacement: a secondary analysis of a controlled clinical trial.BMC musculoskeletal disorders · 2019Trial
- The contralateral knee may not be a valid control for biomechanical outcomes after unilateral total knee arthroplasty.Gait & posture · 2019Trial
- Influence of Hip Abductor Strength on Functional Outcomes Before and After Total Knee Arthroplasty: Post Hoc Analysis of a Randomized Controlled Trial.Physical therapy · 2017Trial
- Effect of limited ischemia time on the amount and function of mitochondria within human skeletal muscle cells.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2016Trial
- Tourniquet-induced ischaemia during total knee arthroplasty results in higher proteolytic activities within vastus medialis cells: a randomized clinical trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Trial
- Minimal important improvement thresholds for the six-minute walk test in a knee arthroplasty cohort: triangulation of anchor- and distribution-based methods.BMC musculoskeletal disorders · 2016Trial
- Does the addition of hip strengthening exercises improve outcomes following total knee arthroplasty? A study protocol for a randomized trial.BMC musculoskeletal disorders · 2016Trial
- Does Tourniquet Use in TKA Affect Recovery of Lower Extremity Strength and Function? A Randomized Trial.Clinical orthopaedics and related research · 2016Trial
- Effects of Weight-Bearing Biofeedback Training on Functional Movement Patterns Following Total Knee Arthroplasty: A Randomized Controlled Trial.The Journal of orthopaedic and sports physical therapy · 2015Trial
- Essential amino acid supplementation in patients following total knee arthroplasty.The Journal of clinical investigation · 2013Trial
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundTemporal-spatial gait parameters improve following total knee arthroplasty (TKA) but lower limb kinematics and moments fail to match those of age-matched healthy individuals. The aim of this study was to determine whether quadriceps strength, clinical measures of knee function, lower limb kinematics, and joint moments improve following arthroplasty and normalize over time.
methodsTwelve patients underwent total knee arthroplasty were tested at 3 and 12 months following surgery. Twelve matched controls were also tested. All underwent quadriceps strength testing and gait analysis to calculate knee joint kinematics and kinetics. Function was assessed using clinical tests and self-report.
findingsAll clinical measures except for quadriceps strength significantly improved from 3 to 12 months. Gait asymmetry was observed at 3 months (lower stance times, peak knee flexion angle, range of motion and vertical ground reaction force), but ankle, knee and hip moments contributing to the total limb support moment were equivalent between legs. At 12 months, gait speed remained significantly slower than controls. Inter-limb differences in peak knee flexion angle and range of motion persisted. Greater hip and lower knee moments were evident in the operated limb, compared to the non-operated limb and controls. Quadriceps strength was positively correlated with faster times on the Time Up and Go and Stair Climbing Test and greater distances during the 6 Minute Walk test.
interpretationPatients who have undergone TKA demonstrate improvements in function as measured by self-report and functional performance measures. Gait becomes more symmetric and quadriceps strength becomes stronger. Some approached the values of healthy control subjects. Important differences still remain however. The larger hip extensor contribution to the total support moment may be to compensate for the diminished knee extensor contribution during level walking. Since instrumented gait analysis and functional performance measures appear to reflect different aspects of recovery following total knee replacement, both should be considered when evaluating gait and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.