Trial reportEuropean journal of nutrition2007
Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects.
Trial report in European journal of nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Metabolomic biomarkers of low BMD: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Trial
- Trial
- Serum untargeted metabolomic profile of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.The American journal of clinical nutrition · 2018Trial
- Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations.The American journal of clinical nutrition · 2014Trial
- Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients.PloS one · 2013Trial
- Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.The American journal of clinical nutrition · 2010Trial
- Calibration of citrus intake assessed by food frequency questionnaires using urinary proline betaine in an observational study setting.The American journal of clinical nutrition · 2024Observational
- Untargeted metabolomic analysis investigating links between unprocessed red meat intake and markers of inflammation.The American journal of clinical nutrition · 2023Article
- Dietary metabolic signatures and cardiometabolic risk.European heart journal · 2023Article
- Metabolomics application for the design of an optimal diet.Journal of preventive medicine and hygiene · 2022Review
- Metabolomic Markers of Southern Dietary Patterns in the Jackson Heart Study.Molecular nutrition & food research · 2021Article
- Identification and Reproducibility of Plasma Metabolomic Biomarkers of Habitual Food Intake in a US Diet Validation Study.Metabolites · 2020Article
- Metabolic signatures associated with Western and Prudent dietary patterns in women.The American journal of clinical nutrition · 2020Observational
- MtpB, a member of the MttB superfamily from the human intestinal acetogenThe Journal of biological chemistry · 2019Article
- Metabolomics and Microbiomes as Potential Tools to Evaluate the Effects of the Mediterranean Diet.Nutrients · 2019Review
- Paving the Way to Precision Nutrition Through Metabolomics.Frontiers in nutrition · 2019Review
- Article
- Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.Radiation research · 2017Article
- A scheme for a flexible classification of dietary and health biomarkers.Genes & nutrition · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProline betaine (PB), a glycine betaine (GB) analogue found in citrus foods, increases urinary GB loss and plasma total homocysteine (tHcy) concentrations in rats. Its presence in human plasma is associated with increased GB excretion.
aimTo compare the effects of dietary levels of PB on GB excretion, and on plasma tHcy and GB concentrations in healthy volunteers.
methodsIn a randomized crossover study, eight healthy males (18-50 years) ingested either 750 mL orange juice (containing 0.545 g PB), a PB supplement (0.545 g PB dissolved in 750 mL apple juice), or 750 mL apple juice (control). Plasma PB, GB and tHcy, and urine PB, GB and creatinine concentrations were measured hourly for 6 h and at 24 h post-treatment.
resultsPlasma tHcy concentrations were not increased (relative to control) following ingestion of either orange juice or PB supplement. Both treatments produced a significant increase in plasma PB concentrations (P < 0.001), this effect being greater following orange juice compared with PB supplement (P < 0.05, 1-2 h). Urinary excretion of PB was greater than the control following both orange juice (P < 0.001) and PB supplement (P < 0.001), from 2 to 24 h post-treatment. This increase in PB excretion was significantly greater following orange juice compared with PB supplement with higher peak excretion (Cmax difference, P = 0.008). GB excretion was significantly greater following ingestion of orange juice compared with PB in apple juice (P = 0.007) and apple juice control (P < 0.001) in the first 2 h post-ingestion.
conclusionsPB administered in dietary doses had little effect on plasma tHcy concentrations in healthy humans. Ingestion of PB in orange juice compared with PB alone resulted in greater increases in the urinary excretion of PB and GB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.