ArticleMolecular diversity
Evidence for positive Darwinian selection on the hepcidin gene of Perciform and Pleuronectiform fishes.
Article in Molecular diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Analysis of In Silico Properties and In Vitro Immunomodulatory Effects of Seven Synthetic Host Defence Peptides in Gilthead Seabream (Sparus aurata) Leucocytes.Marine biotechnology (New York, N.Y.) · 2025Article
- An Update on the Therapeutic Potential of Antimicrobial Peptides againstPharmaceuticals (Basel, Switzerland) · 2023Review
- Comparative study on antibacterial characteristics of the multiple liver expressed antimicrobial peptides (LEAPs) in teleost fish.Frontiers in immunology · 2023Article
- The Antimicrobial Peptide LJ-hep2 fromMarine drugs · 2022Article
- The Era of Antimicrobial Peptides: Use of Hepcidins to Prevent or Treat Bacterial Infections and Iron Disorders.Frontiers in immunology · 2021Article
- The Diverse Piscidin Repertoire of the European Sea Bass (International journal of molecular sciences · 2020Article
- An improved genome assembly forCommunications biology · 2018Article
- Molecular Characterisation of a Novel Isoform of Hepatic Antimicrobial Peptide, Hepcidin (Le-Hepc), from Leiognathus equulus and Analysis of Its Functional Properties In Silico.Probiotics and antimicrobial proteins · 2017Article
- Review
- Article
- Antimicrobial peptides from fish.Pharmaceuticals (Basel, Switzerland) · 2014Article
- Molecular Characterisation and Phylogenetic Analysis of a Novel Isoform of Hepatic Antimicrobial Peptide, Hepcidin (Zc-hepc1), from the Coral Fish Moorish idol, Zanclus cornutus (Linnaeus, 1758).Probiotics and antimicrobial proteins · 2013Article
- A Novel Isoform of the Hepatic Antimicrobial Peptide, Hepcidin (Hepc-CB1), from a Deep-Sea Fish, the Spinyjaw Greeneye Chlorophthalmus bicornis (Norman, 1939): Molecular Characterisation and Phylogeny.Probiotics and antimicrobial proteins · 2013Article
- Article
- Miiuy croaker hepcidin gene and comparative analyses reveal evidence for positive selection.PloS one · 2012Article
- Dynamic programming procedure for searching optimal models to estimate substitution rates based on the maximum-likelihood method.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Characterization of the major histocompatibility complex class II genes in miiuy croaker.PloS one · 2011Article
- Article
- The hepcidin-binding site on ferroportin is evolutionarily conserved.Cell metabolism · 2008Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepcidin is a small cysteine-rich peptide that plays an important role in antimicrobial activity and in maintaining iron homeostasis in vertebrates. Here we report on the underlying mechanism that maintains high sequence diversities among the hepcidin-like variants of perciform and pleuronectiform fishes. In contrast to mammals, maximum likelihood-based codon substitution analyses revealed that positive Darwinian selection (nonsynonymous to synonymous substitution, omega > 1) is the likely cause of accelerated rate of amino acid substitutions in the hepcidin mature peptide region of these fishes. Comparison of models incorporating positive selection (omega > 1) at certain sites with models not incorporating positive selection (omega < 1) failed to reject (p = 0) the evidence of positive selection among the codon sites of percifom and pleuronectiform hepcidin. The adaptive evolution of this peptide in perciform and pleuronectiform fishes might be directed by pathogens when the host is exposed to new habitats/environments.
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