ArticlePflugers Archiv : European journal of physiology2008
Atomic force microscopy visualises a hydrophobic meshwork in the central channel of the nuclear pore.
Article in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Material Removal on Hydrogen-Terminated Diamond Surface via AFM Tip-Based Local Anodic Oxidation.Micromachines · 2025Article
- Mutation in XPO5 causes adult-onset autosomal dominant familial focal segmental glomerulosclerosis.Human genomics · 2022Article
- Atomic Force Microscopy for Structural and Biophysical Investigations on Nuclear Pore Complexes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Role of Nucleoporins and Transport Receptors in Cell Differentiation.Frontiers in physiology · 2020Review
- Spatiotemporal dynamics of the nuclear pore complex transport barrier resolved by high-speed atomic force microscopy.Nature nanotechnology · 2016Article
- MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.Biophysical journal · 2015Article
- Role of molecular charge in nucleocytoplasmic transport.PloS one · 2014Article
- Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex.Journal of cell science · 2010Article
- Hydrophilic linkers and polar contacts affect aggregation of FG repeat peptides.Biophysical journal · 2010Article
- Stable, non-destructive immobilization of native nuclear membranes to micro-structured PDMS for single-molecule force spectroscopy.Chemphyschem : a European journal of chemical physics and physical chemistry · 2009Article
- Apoptosis leads to a degradation of vital components of active nuclear transport and a dissociation of the nuclear lamina.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Distinct, but not completely separate spatial transport routes in the nuclear pore complex.Nucleus (Austin, Tex.)Review
- Permeating the nuclear pore complex.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear pore complexes (NPCs) mediate and control the transport of virtually all material between the cytosol and the nucleus. It is, therefore, unsurprising that they have long taken centre stage in physiology. A precise understanding of the NPC structure and function that remain to be thoroughly investigated yet is, thus, of crucial importance. The NPC can mediate transport both actively and passively. It remains to be clarified, however, whether transport of small molecules and macromolecules proceeds through the same route in the NPC. Furthermore, it has been shown that surface hydrophobicity represents a major sorting criterion for the active transport through NPCs. Transport factors like importin beta, which exhibit a rather large surface hydrophobicity, bind to their cargo and are believed to interact with a supposedly hydrophobic meshwork that is assumed to reside in the central channel of the NPC but has not yet been visualised. This interaction is presumed to lead to a partial breakdown of the meshwork, thereby, permitting the transport-cargo complexes to pass through. In this study, by using the nano-imaging approach, atomic force microscopy, we visualised under near-physiological conditions, for the first time, the presence of a hydrophobic meshwork in the NPC central channel. Furthermore, our data lend strong support for the existence of two segregated transport routes in the NPC.
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