ArticlePlant molecular biology2008
Modulation of intracellular proline levels affects flowering time and inflorescence architecture in Arabidopsis.
Article in Plant molecular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 151 citations in OpenAlex.
- The circular RNA circP5CS1 coordinates plant immunity by sequestering miR167 to modulate ARF6/8 signaling and repressing P5CS1-mediated proline biosynthesis in Arabidopsis.Plant communications · 2026Article
- Article
- Beyond osmoprotection: the expanding roles of proline in plant signalling and development.Biologia futura · 2026Review
- Heterologous expression of MfWRKY40 enhanced drought resistance of alfalfa.BMC plant biology · 2026Article
- Transcriptomic Analysis of Osmotic Stress-Tolerant Somatic Embryos ofInternational journal of molecular sciences · 2025Article
- Salinity survival: molecular mechanisms and adaptive strategies in plants.Frontiers in plant science · 2025Review
- Proline and ROS: A Unified Mechanism in Plant Development and Stress Response?Plants (Basel, Switzerland) · 2024Review
- Proline Metabolism Genes in Transgenic Plants: Meta-Analysis under Drought and Salt Stress.Plants (Basel, Switzerland) · 2024Article
- Long-term nitrogen fertilization alters the partitioning of amino acids between citrus leaves and fruits.Frontiers in plant science · 2024Article
- Physiological and metabolic analyses reveal the proline-mediated flowering delay mechanism inFrontiers in plant science · 2024Article
- Comparative Proteomic and Metabonomic Profiling of Buds with Different Flowering Capabilities Reveal Novel Regulatory Mechanisms of Flowering in Apple.Plants (Basel, Switzerland) · 2023Article
- Adapting to Climate Change withPlants (Basel, Switzerland) · 2023Review
- Salinity-Triggered Responses in Plant Apical Meristems for Developmental Plasticity.International journal of molecular sciences · 2023Review
- Loss function ofFrontiers in plant science · 2023Article
- Effect of Exogenous Application of Nicotinic Acid on Morpho-Physiological Characteristics ofPlants (Basel, Switzerland) · 2022Article
- Proline Affects Flowering Time in Arabidopsis by Modulating FLC Expression: A Clue of Epigenetic Regulation?Plants (Basel, Switzerland) · 2022Article
- Interplay between Proline Metabolism and ROS in the Fine Tuning of Root-Meristem Size inPlants (Basel, Switzerland) · 2022Article
- Role of ACC deaminase producing bacteria for abiotic stress management and sustainable agriculture production.Environmental science and pollution research international · 2022Review
- Understanding the roles of osmolytes for acclimatizing plants to changing environment: a review of potential mechanism.Plant signaling & behavior · 2021Review
- Dehydration-Induced WRKY Transcriptional Factor MfWRKY70 ofBiomolecules · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported previously that the plant oncogene rolD anticipates and stimulates flowering in Nicotiana tabacum, and encodes ornithine cyclodeaminase, an enzyme catalysing the conversion of ornithine to proline. To investigate on the possible role of proline in flowering, we altered the expression of AtP5CS1, encoding the rate-limiting enzyme of proline biosynthesis in plants. Accordingly we characterized a mutant line containing a T-DNA insertion into AtP5CS1 and introduced in Arabidopsis thaliana AtP5CS1 under the control of the CaMV35S promoter. As expected homozygous p5cs1 mutants behaved as late flowering. In addition p5cs1 mutants exhibited a shorter size and contained lower levels of proline, compared to wild type. 35S-P5CS1 plants, manifested, early in development, overexpression of P5CS1 and accumulation of proline, leading to early flowering, both under long- and short-day conditions. Later in development, down-regulation of P5CS1 occurred in 35S-P5CS1 leaves, leading to proline reduction, and, in turn, impaired bolting and stunted growth. Salt-stress restored expression of P5CS1 and proline accumulation in P5CS1-transformed plants, as well as rescuing growth. Our data suggest that proline plays a key role in flower transition, bolting and coflorescence formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.