ArticleJournal of computational neuroscience2008
Lateral dendritic shunt inhibition can regularize mitral cell spike patterning.
Article in Journal of computational neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Anatomical and Functional Connectivity at the Dendrodendritic Reciprocal Mitral Cell-Granule Cell Synapse: Impact on Recurrent and Lateral Inhibition.Frontiers in neural circuits · 2022Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Olfactory bulb plasticity ensures proper olfaction after severe impairment in postnatal neurogenesis.Scientific reports · 2017Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb.PloS one · 2016Article
- Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.Physiological reports · 2015Article
- Bulbar microcircuit model predicts connectivity and roles of interneurons in odor coding.PloS one · 2015Article
- Bilinearity in spatiotemporal integration of synaptic inputs.PLoS computational biology · 2014Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A model of electrophysiological heterogeneity in periglomerular cells.Frontiers in computational neuroscience · 2013Article
- Sparse distributed representation of odors in a large-scale olfactory bulb circuit.PLoS computational biology · 2013Article
- Distinct spatiotemporal activity in principal neurons of the mouse olfactory bulb in anesthetized and awake states.Frontiers in neural circuits · 2013Article
- The periglomerular cell of the olfactory bulb and its role in controlling mitral cell spiking: a computational model.PloS one · 2013Article
- Phenomenological incorporation of nonlinear dendritic integration using integrate-and-fire neuronal frameworks.PloS one · 2013Article
- Intraglomerular inhibition shapes the strength and temporal structure of glomerular output.Journal of neurophysiology · 2012Article
- Neurogenesis drives stimulus decorrelation in a model of the olfactory bulb.PLoS computational biology · 2012Article
- Calcium currents of olfactory bulb juxtaglomerular cells: profile and multiple conductance plateau potential simulation.Neuroscience · 2011Article
- Effect of sniffing on the temporal structure of mitral/tufted cell output from the olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Biophysical model for gamma rhythms in the olfactory bulb via subthreshold oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Temporal structure of receptor neuron input to the olfactory bulb imaged in behaving rats.Journal of neurophysiology · 2009Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Mitral cells, the principal output neurons of the olfactory bulb, receive direct synaptic activation from primary sensory neurons. Shunting inhibitory inputs delivered by granule cell interneurons onto mitral cell lateral dendrites, while poorly positioned to prevent spike initiation, are believed to influence spike timing and underlie coordinated field potential oscillations. We investigated this phenomenon in a reduced compartmental mitral cell model suitable for incorporation into network simulations. Lateral dendritic shunt conductances delayed spiking to a degree dependent on both their electrotonic distance and phase of onset. Moreover, when the afferent activation of mitral cells was loosely coordinated in time, recurrent inhibition significantly narrowed the distribution of mitral cell spike times, illustrating a tendency towards coordinated synchronous activity. However, if mitral cell activity was initially disorganized, recurrent inhibition actually increased the variance in spike timing. This result suggests an essential role for early mechanisms of temporal coordination in olfaction, such as sniffing and the initial synchronization of mitral cell intrinsic oscillations by periglomerular cell-mediated inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.