Trial reportClinical research in cardiology : official journal of the German Cardiac Society2008
Productivity loss as a major component of disease-related costs in patients with hypercholesterolemia in Germany.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Low-fat diets for acquired hypercholesterolaemia.The Cochrane database of systematic reviews · 2011Pooled it
- Intervention study shows outpatient cardiac rehabilitation to be economically at least as attractive as inpatient rehabilitation.Clinical research in cardiology : official journal of the German Cardiac Society · 2009Trial
- Costs attributable to hypercholesterolemia in a single period and over the life cycle.The European journal of health economics : HEPAC : health economics in prevention and care · 2024Article
- Health Economic Evaluation of a Controlled Lifestyle Intervention: The Healthy Lifestyle Community Program (Cohort 2; HLCP-2).Nutrients · 2023Article
- The economic burden of self-reported and undiagnosed cardiovascular diseases and diabetes on Indonesian households.PloS one · 2014Article
- Prevalence and overlap of different lipid abnormalities in statin-treated patients at high cardiovascular risk in clinical practice in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
- Effectiveness, safety and cost of drug substitution in hypertension.British journal of clinical pharmacology · 2010Article
- Cardiovascular and economic outcomes after initiation of lipid-lowering therapy with atorvastatin vs simvastatin in an employed population.Mayo Clinic proceedings · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHypercholesterolemia is a common risk factor for cardiovascular diseases; however, there are only few data available on associated costs. The objective of this study is, therefore, to analyse direct and indirect costs in patients with hypercholesterolemia and to determine predictors of costs.
methodsThe ORBITAL Study is a randomised controlled trial evaluating the effectiveness of a compliance-enhancing program in patients with statin therapy. Consecutive patients eligible for statin therapy according to the Joint European Guidelines were enrolled nationwide in 1961 primary care practices in Germany. For the present cost-of-illness analysis, patients were asked retrospectively about medical resource use and employment status in the 6 months preceding enrollment. The perspective chosen was societal. Factors associated with costs were determined using linear regression.
resultsA total of 7,640 patients (56% men, mean age 60 +/- 10 years, and 44% women, 64 +/- 10 years) were included. Of these patients, 32% were employed, 17% had a history of myocardial infarction, 7% a history of stroke, 58% had hypertension, and 29% diabetes. Total disease-related costs amounted to a mean of 2,498 +/- 4,898 Euros per patient over 6 months, comprising direct (44%) and indirect (56%) costs. Disease-related early retirement was responsible for 42% of costs, followed by hospital visits (19%), medication (15%), workdays lost (14%), physician visits (5%), outpatient therapy (2%), and rehabilitation (2%). In multivariable analyses, factors associated with direct costs included coronary interventions, risk stratum, and medical history. Factors associated with indirect costs included disease-related early retirement, other socio-economic and lifestyle factors, coronary interventions, risk stratum, and medical history.
conclusionThe considerable economic burden associated with hypercholesterolemia indicates the need to assess long-term cost-effectiveness of health care programs in patients with this disorder.
Indexed as
Identifiers
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Registered trials
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