ArticleExtremophiles : life under extreme conditions2008
First characterisation of the active oligomer form of sulfur oxygenase reductase from the bacterium Aquifex aeolicus.
Article in Extremophiles : life under extreme conditions, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- A review on bacterial and archaeal thermostable sulfur oxidoreductases (SORS)-an insight into the biochemical, molecular and in-silico structural comparative analysis of a neglected thermostable enzyme of industrial significance.Archives of microbiology · 2022Review
- Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase.PloS one · 2022Article
- Genomic Characterization and Environmental Distribution of a Thermophilic AnaerobeMicroorganisms · 2020Article
- Crystallographic and cryogenic electron microscopic structures and enzymatic characterization of sulfur oxygenase reductase fromJournal of structural biology: X · 2020Article
- S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - Biochemical and structural studies.International journal of biological macromolecules · 2017Article
- The Sulfur Oxygenase Reductase Activity Assay: Catalyzing a Reaction with Elemental Sulfur as Substrate at High Temperatures.Bio-protocol · 2017Article
- A Sulfur Oxygenase from the Haloalkaliphilic Bacterium Thioalkalivibrio paradoxus with Atypically Low Reductase Activity.Journal of bacteriology · 2017Article
- Sulfur Oxygenase Reductase (Sor) in the Moderately Thermoacidophilic Leaching Bacteria: Studies in Sulfobacillus thermosulfidooxidans and Acidithiobacillus caldus.Microorganisms · 2015Article
- Whole-genome sequencing reveals novel insights into sulfur oxidation in the extremophile Acidithiobacillus thiooxidans.BMC microbiology · 2014Article
- Metabolic evolution of a deep-branching hyperthermophilic chemoautotrophic bacterium.PloS one · 2014Article
- Rhodanese functions as sulfur supplier for key enzymes in sulfur energy metabolism.The Journal of biological chemistry · 2012Article
- The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme.Journal of bacteriology · 2012Article
- Substrate pathways and mechanisms of inhibition in the sulfur oxygenase reductase of acidianus ambivalens.Frontiers in microbiology · 2011Article
- New functional sulfide oxidase-oxygen reductase supercomplex in the membrane of the hyperthermophilic bacterium Aquifex aeolicus.The Journal of biological chemistry · 2010Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Sulfur oxygenase reductase (SOR) enzyme is responsible for the initial oxidation step of elemental sulfur in archaea. Curiously, Aquifex aeolicus, a hyperthermophilic, chemolithoautotrophic and microaerophilic bacterium, has the SOR-encoding gene in its genome. We showed, for the first time the presence of the SOR enzyme in A. aeolicus, its gene was cloned and recombinantly expressed in Escherichia coli and the protein was purified and characterised. It is a 16 homo-oligomer of approximately 600 kDa that contains iron atoms indispensable for the enzyme activity. The optimal temperature of SOR activity is 80 degrees C and it is inactive at 20 degrees C. Studies of the factors involved in getting the fully active molecule at high temperature show clearly that (1) incubation at high temperature induces more homogeneous form of the enzyme, (2) conformational changes observed at high temperature are required to get the fully active molecule and (3) acquisition of an active conformation induced by the temperature seems to be more important than the subunit number. Differences between A. aeolicus SOR and the archaea SORs are described.
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