ArticlePloS one2007
Time processing in Huntington's disease: a group-control study.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.PloS one · 2012Trial
- Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease.Brain and behavior · 2024Article
- Phylogenic evolution of beat perception and synchronization: a comparative neuroscience perspective.Frontiers in systems neuroscience · 2023Review
- Time estimation and arousal responses in dopa-responsive dystonia.Scientific reports · 2022Article
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- A novel approach to intra-individual performance variability in ADHD.European child & adolescent psychiatry · 2021Article
- Deep Learning Based on Event-Related EEG Differentiates Children with ADHD from Healthy Controls.Journal of clinical medicine · 2019Article
- International Guidelines for the Treatment of Huntington's Disease.Frontiers in neurology · 2019Article
- Metastable States of Multiscale Brain Networks Are Keys to Crack the Timing Problem.Frontiers in computational neuroscience · 2018Article
- The Alteration of Emotion Regulation Precedes the Deficits in Interval Timing in the BACHD Rat Model for Huntington Disease.Frontiers in integrative neuroscience · 2018Article
- Time perception impairment in early-to-moderate stages of Huntington's disease is related to memory deficits.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Time Processing and Motor Control in Movement Disorders.Frontiers in human neuroscience · 2016Review
- Time estimation and production in HIV-associated neurocognitive disorders (HAND).Journal of the International Neuropsychological Society : JINS · 2015Article
- Variability in interval production is due to timing-dependent deficits in Huntington's disease.Movement disorders : official journal of the Movement Disorder Society · 2014Article
- Impaired motor speech performance in Huntington's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Time dysperception perspective for acquired brain injury.Frontiers in neurology · 2014Review
- Music perception and movement deterioration in Huntington's disease.PLoS currents · 2011Article
- Behavioral and in vivo electrophysiological evidence for presymptomatic alteration of prefrontostriatal processing in the transgenic rat model for huntington disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Behavioral sensitivity of temporally modulated striatal neurons.Frontiers in integrative neuroscience · 2011Article
- Tapping linked to function and structure in premanifest and symptomatic Huntington disease.Neurology · 2010Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background"Timing" processes are mediated via a disturbed neuronal network including the basal ganglia. Brain structures important for "timing" are also discussed to be critical for the deterioration of movements in Huntington's disease (HD). Changes in "timing processes" are found in HD, but no study has varied the degree of motor demands in timing functions in parallel in HD. It may be hypothesized that timing functions may be deteriorated to a different extent in motor and non-motor timing, because in motor timing the underlying brain structures may be more demanding than in non-motor timing. METHODOLOGY/PRINCIPLE
findingsWE ASSESSED TIMING IN TWO DIFFERENT EXPERIMENTS: a time-estimation (TE) and a time-discrimination (TD) task. The demand on motor functions is high in the TE-task and low in the TD-task. Furthermore, general motor ability was assessed at different complexity levels. A presymptomatic (pHD), a symptomatic (HD) and a control group were investigated. We found a decline in timing functions when demands on the motor system were high (TE-task), in HD and even in pHD, compared to controls. In non-motor timing (TD task) and in the assessment of general motor ability, performance in the pHD-group was comparable to the controls and better than in the symptomatic group. Performance in both timing tasks was related to the duration until the estimated age of onset in pHDs. CONCLUSIONS/SIGNIFICANCE: The study shows a selective deterioration of time-estimation processes in symptomatic and even presymptomatic Huntington's disease. Time-discrimination processes were not affected in both patient groups. The relation of timing performance to the duration until the estimated age of onset in pHD is of clinical importance.
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