ArticlePPAR research2007
RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury.
Article in PPAR research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis.Neurology and therapy · 2022Review
- The Diverse Manifestations of Regeneration and Why We Need to Study Them.Cold Spring Harbor perspectives in biology · 2021Article
- Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Pharmacological Activation of RXR-α Promotes Hematoma Absorption via a PPAR-γ-dependent Pathway After Intracerebral Hemorrhage.Neuroscience bulletin · 2021Article
- Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target.International journal of molecular sciences · 2021Review
- Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt.Neural regeneration research · 2018Article
- Identification of key genes and pathways associated with spinal cord injury.Molecular medicine reports · 2017Article
- Role of Peroxisome Proliferator-Activated Receptor γ in Ocular Diseases.Journal of ophthalmology · 2015Review
- Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?Frontiers in cellular neuroscience · 2014Review
- Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?Neurotoxicity research · 2013Review
- Gene expression profiling of liver X receptor α and Bcl-2-associated X protein in experimental transection spinal cord-injured rats.The journal of spinal cord medicine · 2013Article
- New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury.PPAR research · 2012Article
- Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?Parkinson's disease · 2011Article
- Intrathecal rosiglitazone acts at peroxisome proliferator-activated receptor-gamma to rapidly inhibit neuropathic pain in rats.The journal of pain · 2008Article
- Peroxisome proliferator-activated receptors: "key" regulators of neuroinflammation after traumatic brain injury.PPAR research · 2008Article
- [Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome].Molekuliarnaia biologiiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retinoid acid receptors (RAR) and peroxisome proliferator-activated receptors (PPAR) have been implicated in the regulation of inflammatory reactions. Both receptor families contain ligand-activated transcription factors which form heterodimers with retinoid X receptors (RXR). We review data that imply RAR/RXR and PPAR/RXR pathways in physiological reactions after spinal cord injury. Experiments show how RAR signaling may improve axonal regeneration and modulate reactions of glia cells. While anti-inflammatory properties of PPAR are well documented in the periphery, their possible roles in the central nervous system have only recently become evident. Due to its anti-inflammatory function this transcription factor family promises to be a useful target after spinal cord or brain lesions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.