ArticleInternational journal of geriatric psychiatry2008
APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.
Article in International journal of geriatric psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Does Gender Influence the Relationship Between High Blood Pressure and Dementia? Highlighting Areas for Further Investigation.Journal of Alzheimer's disease : JAD · 2020Pooled it
- The association of antidepressant drug usage with cognitive impairment or dementia, including Alzheimer disease: A systematic review and meta-analysis.Depression and anxiety · 2017Pooled it
- Depressive Symptoms and Amyloid Pathology.JAMA psychiatry · 2025Article
- Exploring the Genetic Landscape of Mild Behavioral Impairment as an Early Marker of Cognitive Decline: An Updated Review Focusing on Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele.Brain pathology (Zurich, Switzerland) · 2024Review
- Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy.Frontiers in neuroscience · 2024Article
- Effects of obesogenic diet and 17β-estradiol in female mice withFrontiers in aging neuroscience · 2024Article
- Malnutrition and neuropsychiatric symptoms in dementia: the Cache County Dementia Progression Study.International psychogeriatrics · 2023Observational
- Assessing the Role of Past Depression in Patients with Mild Cognitive Impairment, with and without Biomarkers for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
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- The Role of Sex in Genetic Association Studies of Depression.Journal of psychiatry and brain science · 2022Article
- Analyzing the genes and pathways related to major depressive disorder via a systems biology approach.Brain and behavior · 2020Article
- Fluid Intelligence Predicts Change in Depressive Symptoms in Later Life: The Lothian Birth Cohort 1936.Psychological science · 2018Article
- Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples.Frontiers in neuroscience · 2018Article
- Alzheimer Disease and Selected Risk Factors Disrupt a Co-regulation of Monoamine Oxidase-A/B in the Hippocampus, but Not in the Cortex.Frontiers in neuroscience · 2018Article
- A Depressive Endophenotype for Predicting Cognitive Decline among Mexican American Adults and Elders.Journal of Alzheimer's disease : JAD · 2016Article
- APOE ϵ4, rated life experiences, and affect among centenarians.Aging & mental health · 2014Article
- Behavioral and psychological symptoms in Alzheimer's disease.BioMed research international · 2014Review
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe association between the APOE epsilon4 allele and depression was investigated in a retrospective study of 323 AD patients.
methodsPatients were divided into demographically comparable groups based on the presence or absence of depression.
resultsResults showed that the frequency of APOE epsilon4 allele was significantly higher in the depressed vs non-depressed AD patients (72% and 58%, respectively), and an interaction revealed that women possessing the APOE epsilon4 allele were almost four times more likely to be depressed than those without the epsilon4 allele.
conclusionResults are consistent with recent suggestions that the APOE epsilon4 genotype may be over-represented among depressed women with AD and highlight the need for additional research investigating the links between APOE genotype, mood, and gender.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.