ArticleEndocrine pathology2007
Follicular variant papillary thyroid carcinoma arising in struma ovarii.
Article in Endocrine pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 70 citations in OpenAlex.
- Malignant struma ovarii: clinicopathological and molecular features in a series of nine cases.Virchows Archiv : an international journal of pathology · 2026Article
- Malignant Struma Ovarii: A Rare Manifestation of Ectopic Thyroid Cancer.JCEM case reports · 2025Article
- RET/PTC rearrangement in papillary thyroid carcinoma arising in malignant struma ovarii with abdominal wall metastasis and cervical thyroid gland: a case report and review of the literature.Thyroid research · 2023Article
- Identifying the Carcinogenic Mechanism of Malignant Struma Ovarii Using Whole-Exome Sequencing and DNA Methylation Analysis.Current issues in molecular biology · 2023Article
- Case Report: Recurrent Malignant Struma Ovarii With Hyperthyroidism and Metastases, A Rare Case Report and Review of the Literature.Pathology oncology research : POR · 2022Review
- Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary.BMC cancer · 2021Article
- Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.Endocrine · 2021Article
- Papillary Thyroid Cancer in a Struma Ovarii in a 17-Year-Old Nulliparous Patient: A case Report.Diagnostics (Basel, Switzerland) · 2020Article
- Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With DifferentJournal of the Endocrine Society · 2018Article
- Pancreatic Struma with Papillary Thyroid Carcinoma: a Diagnostic Dilemma.Endocrine pathology · 2017Article
- Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature.Clinical medicine insights. Endocrinology and diabetes · 2017Article
- A Hormonally Active Malignant Struma Ovarii.Case reports in oncological medicine · 2016Article
- Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii.Endocrine pathology · 2015Article
- Follicular proliferative lesion arising in struma ovarii.Journal of pathology and translational medicine · 2015Article
- Struma ovarii simulating ovarian sertoli cell tumor: a case report with literature review.International journal of clinical and experimental pathology · 2013Review
- Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report.World journal of surgical oncology · 2012Article
- Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer.Thyroid : official journal of the American Thyroid Association · 2010Review
- A case of papillary thyroid carcinoma in struma ovarii and review of the literature.Pathology research international · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Struma ovarii is a rare monodermal ovarian teratoma in which thyroid tissue is the predominant or exclusive element. Malignant transformation is known to occur, usually as classical papillary thyroid carcinoma (PTC). However, the recognition of follicular variant PTC raises the possibility of similar malignancy arising in struma ovarii. We examined 13 cases of struma ovarii to determine if these lesions can exhibit histological, immunohistochemical, and/or molecular features of follicular variant PTC. Ten of these had atypical histology, cytologic features of PTC, and all ten showed diffuse positivity for CK19; eight of these were also positive for HMBE-1. Mutational analysis for BRAF identified no V600E mutations. However, seven of the ten cases with features of follicular variant PTC exhibited a rearranged in transformation (RET)/PTC rearrangement by reverse transcriptase polymerase chain reaction (RT-PCR). The three cases considered to be benign based on histologic and cytologic criteria were negative for CK19 and HBME-1 by immunohistochemistry, and had no evidence of BRAF mutation or ret/PTC-1 and ret/PTC-3 rearrangements. These results indicate that follicular variant PTC can occur in struma ovarii and that such lesions exhibit the same morphologic and immunohistochemical profile as follicular variant PTC in thyroid. The application of molecular testing to verify the diagnosis can be valuable, as these lesions may harbor ret/PTC gene rearrangements.
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