ArticleJournal of molecular evolution2008
The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Melatonin Mitigates Cd-Induced Growth Repression and RNA mPlants (Basel, Switzerland) · 2025Article
- Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases.Genes & diseases · 2023Review
- Immunostimulatory effects of marine algae extracts on in vitro antigen-presenting cell activation and in vivo immune cell recruitment.Food science & nutrition · 2023Article
- Emerging Roles of FTO in Neuropsychiatric Disorders.BioMed research international · 2022Review
- Roles of N6-Methyladenosine Demethylase FTO in Malignant Tumors Progression.OncoTargets and therapy · 2021Review
- FTO - A Common Genetic Basis for Obesity and Cancer.Frontiers in genetics · 2020Review
- Small changes, big implications: The impact of mBiochimica et biophysica acta. Gene regulatory mechanisms · 2019Review
- Novel positioning from obesity to cancer: FTO, an mJournal of cancer research and clinical oncology · 2019Review
- The FTO Gene Is Associated with Growth and Omega-3/-6 Ratio in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2018Article
- A fly view on the roles and mechanisms of the mRNA biology · 2017Article
- Complex Relationship between Obesity and the Fat Mass and Obesity Locus.International journal of biological sciences · 2017Review
- Role of a common variant of Fat Mass and Obesity associated (FTO) gene in obesity and coronary artery disease in subjects from Punjab, Pakistan: a case control study.Lipids in health and disease · 2016Article
- The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.The Journal of biological chemistry · 2015Review
- Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes.Genome biology · 2015Article
- Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study.BioMed research international · 2015Article
- Gene expression regulation mediated through reversible m⁶A RNA methylation.Nature reviews. Genetics · 2014Review
- Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.International journal of endocrinology · 2014Review
- Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice.American journal of human genetics · 2013Article
- Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.RNA biology · 2013Article
- The genetics of human obesity.Annals of the New York Academy of Sciences · 2013Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human obesity is a main cause of morbidity and mortality. Recently, several studies have demonstrated an association between the FTO gene locus and early onset and severe obesity. To date, the FTO gene has only been discovered in vertebrates. We identified FTO homologs in the complete genome sequences of various evolutionary diverse marine eukaryotic algae, ranging from unicellular photosynthetic picoplankton to a multicellular seaweed. However, FTO homologs appear to be absent from all other completely sequenced genomes of plants, fungi, and invertebrate animals. Although the biological roles of these marine algal FTO homologs are still unknown, these genes will be useful for exploring basic protein features and could hence help unravel the function of the FTO gene in vertebrates and its inferred link with obesity in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.