ArticleImmunogenetics2007
Evidence for myxobacterial origin of eukaryotic defensins.
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity.BMC biology · 2025Article
- Trans-kingdom conservation of mechanism between bacterial actifensin and eukaryotic defensins.npj antimicrobials and resistance · 2025Article
- Discovery of Five Classes of Bacterial Defensins: Ancestral Precursors of Defensins from Eukarya?ACS omega · 2024Article
- In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes.BMC microbiology · 2023Article
- Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19.Infectious diseases and therapy · 2022Review
- Myxobacterial Genomics and Post-Genomics: A Review of Genome Biology, Genome Sequences and Related 'Omics Studies.Microorganisms · 2021Review
- The Syntrophy hypothesis for the origin of eukaryotes revisited.Nature microbiology · 2020Review
- Article
- Medicinal Potentialities of Plant Defensins: A Review with Applied Perspectives.Medicines (Basel, Switzerland) · 2019Review
- Did cis- and trans-defensins derive from a common ancestor?Immunogenetics · 2019Article
- Convergent evolution of defensin sequence, structure and function.Cellular and molecular life sciences : CMLS · 2017Review
- Establishing a reference array for the CS-αβ superfamily of defensive peptides.BMC research notes · 2016Article
- Defensins: antifungal lessons from eukaryotes.Frontiers in microbiology · 2014Review
- Beta-defensins: what are they really doing in the oral cavity?Oral diseases · 2011Review
- Antimicrobial peptides and proteins of the horse--insights into a well-armed organism.Veterinary research · 2011Review
- Article
- Natural History of Innate Host Defense Peptides.Probiotics and antimicrobial proteins · 2009Article
- Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptides.Comparative and functional genomics · 2009Article
- The roles of antimicrobial peptides in innate host defense.Current pharmaceutical design · 2009Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial defensins with the cysteine-stabilized alpha-helical and beta-sheet (CS alpha beta) motif are a large family of ancient, evolutionarily related innate immunity effectors of multicellular organisms. Although the widespread distribution in plants, fungi, and invertebrates suggests their uniqueness to Eukarya, it is unknown whether these eukaryotic defensins originated before or posterior to the emergence of eukaryotes. In this study, we provide evidence in support of the existence of defensin-like peptides (DLPs) in myxobacteria based on structural bioinformatics analysis, which recognized two bacterial peptides with a conserved cysteine-stabilized alpha-helical motif, a nested structural unit of the CS alpha beta motif. Similarity in sequence and structure to fungal DLPs together with restricted distribution to the myxobacteria as well as central role of the myxobacteria in the origin of eukaryotes suggest that the bacterial DLPs represent the ancestor of the eukaryotic defensins and could mediate immune defense of early eukaryotes after gene transfer to the proto-eukaryotic genome. Our work thus offers a basis for further investigation of prokaryotic origin of eukaryotic immune effector molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.