ArticleParasitology research2008
Transcriptome profile of Trypanosoma cruzi-infected cells: simultaneous up- and down-regulation of proliferation inhibitors and promoters.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Trypanosoma cruzi infection induces DNA double-strand breaks and activates DNA damage response pathway in host epithelial cells.Scientific reports · 2024Article
- Cellular Stress and Senescence Induction duringTropical medicine and infectious disease · 2022Review
- DNA damage and oxidative stress in human cells infected by Trypanosoma cruzi.PLoS pathogens · 2021Article
- Transcriptional Studies onFrontiers in cellular and infection microbiology · 2021Review
- Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation.PLoS pathogens · 2020Article
- DNA lesions and repair in trypanosomatids infection.Genetics and molecular biology · 2020Article
- Host-parasite interaction: changes in human placental gene expression induced by Trypanosoma cruzi.Parasites & vectors · 2018Article
- Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection.PLoS pathogens · 2016Article
- Early Trypanosoma cruzi infection reprograms human epithelial cells.BioMed research international · 2014Article
- The MASP family of Trypanosoma cruzi: changes in gene expression and antigenic profile during the acute phase of experimental infection.PLoS neglected tropical diseases · 2012Article
- Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes.Infection and immunity · 2011Article
- Microarray analysis of the mammalian thromboxane receptor-Trypanosoma cruzi interaction.Cell cycle (Georgetown, Tex.) · 2011Article
- Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection.PloS one · 2011Article
- Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand.Chemistry & biodiversity · 2010Article
- Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi.The American journal of tropical medicine and hygiene · 2010Article
- Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines.PLoS neglected tropical diseases · 2010Article
- REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi.The open parasitology journal · 2010Article
- Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes.Microbes and infection · 2009Article
- Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm of nucleated host cells, infection with this parasite is highly likely to affect host cells. We performed an exhaustive transcriptome analysis of T. cruzi-infected HeLa cells using an oligonucleotide microarray containing probes for greater than 47,000 human gene transcripts. In comparison with uninfected cells, those infected with T. cruzi showed greater than threefold up-regulation of 41 genes and greater than threefold down-regulation of 23 genes. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of selected, differentially expressed genes confirmed the microarray data. Many of these up- and down-regulated genes were related to cellular proliferation, including seven up-regulated genes encoding proliferation inhibitors and three down-regulated genes encoding proliferation promoters, strongly suggesting that T. cruzi infection inhibits host cell proliferation, which may allow more time for T. cruzi to replicate and produce its intracellular nests. These findings provide new insight into the molecular mechanisms by which intracellular T. cruzi infection influences the host cell, leading to pathogenicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.