ReviewPflugers Archiv : European journal of physiology2008
Probing cellular microenvironments and tissue remodeling by atomic force microscopy.
Review in Pflugers Archiv : European journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 90 citations in OpenAlex.
- Untangling the web of glioblastoma treatment resistance using a multi-omic and multidisciplinary approach.The American journal of the medical sciences · 2023Review
- Cell Deformation at the Air-Liquid Interface Evokes Intracellular CaFrontiers in physiology · 2021Article
- Simultaneous co-localized super-resolution fluorescence microscopy and atomic force microscopy: combined SIM and AFM platform for the life sciences.Scientific reports · 2020Article
- Effects of methotrexate on the viscoelastic properties of single cells probed by atomic force microscopy.Journal of biological physics · 2016Article
- ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.PLoS genetics · 2016Article
- Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.Journal of cell science · 2014Article
- Longitudinal measurement of extracellular matrix rigidity in 3D tumor models using particle-tracking microrheology.Journal of visualized experiments : JoVE · 2014Article
- Atomic force microscopy determination of Young׳s modulus of bovine extra-ocular tendon fiber bundles.Journal of biomechanics · 2014Article
- Quantification of magnetically induced changes in ECM local apparent stiffness.Biophysical journal · 2014Article
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- The softening of human bladder cancer cells happens at an early stage of the malignancy process.Beilstein journal of nanotechnology · 2014Article
- Techniques for assessing 3-D cell-matrix mechanical interactions in vitro and in vivo.Experimental cell research · 2013Review
- Computational modeling of single-cell migration: the leading role of extracellular matrix fibers.Biophysical journal · 2012Article
- The extracellular matrix remodeled: Interdependency of matrix proteolysis, cell adhesion, and force sensing.Communicative & integrative biology · 2012Article
- Experimental and numerical determination of cellular traction force on polymeric hydrogels.Interface focus · 2011Article
- Mesenchymal stem cell mechanics from the attached to the suspended state.Biophysical journal · 2010Article
- Spatial mapping of the biomechanical properties of the pericellular matrix of articular cartilage measured in situ via atomic force microscopy.Biophysical journal · 2010Article
- Detecting cell-adhesive sites in extracellular matrix using force spectroscopy mapping.Journal of physics. Condensed matter : an Institute of Physics journal · 2010Article
- Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors.Biophysical journal · 2010Article
- Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of cells is strongly determined by the properties of their extracellular microenvironment. Biophysical parameters like environmental stiffness and fiber orientation in the surrounding matrix are important determinants of cell adhesion and migration. Processes like tissue maintenance, wound repair, cancer cell invasion, and morphogenesis depend critically on the ability of cells to actively sense and remodel their surroundings. Pericellular proteolytic activity and adaptation of migration tactics to the environment are strategies to achieve this aim. Little is known about the distinct regulatory mechanisms that are involved in these processes. The system's critical biophysical and biochemical determinants are well accessible by atomic force microscopy (AFM), a unique tool for functional, nanoscale probing and morphometric, high-resolution imaging of processes in live cells. This review highlights common principles of tissue remodeling and focuses on application examples of different AFM techniques, for example elasticity mapping, the combination of AFM and fluorescence microscopy, the morphometric imaging of proteolytic activity, and force spectroscopy applications of single molecules or individual cells. To achieve a more complete understanding of the processes underlying the interaction of cells with their environments, the combination of AFM force spectroscopy experiments will be essential.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.