ArticleSkeletal radiology2008
Changes underlying the dynamic contrast-enhanced MRI response to treatment in rheumatoid arthritis.
Article in Skeletal radiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- High-temporal resolution DCE-MRI improves assessment of intra- and peri-breast lesions categorized as BI-RADS 4.BMC medical imaging · 2023Trial
- Dynamic contrast-enhanced MRI for monitoring bisphosphonate therapy in Paget's disease of bone.Skeletal radiology · 2013Trial
- 3D-printable phantoms for quantitative dynamic contrast-enhanced MRI.Magnetic resonance in medicine · 2025Article
- Diffusion Tensor and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Correlate with Molecular Markers of Inflammation in the Synovium.Diagnostics (Basel, Switzerland) · 2022Article
- Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?Pediatric rheumatology online journal · 2019Article
- High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients.NMR in biomedicine · 2016Article
- Magnetic resonance imaging in patients with granulomatosis with polyangiitis (Wegener's) and subglottic stenosis.Magma (New York, N.Y.) · 2013Article
- The pathogenesis of rheumatoid arthritis in radiological studies. Part II: Imaging studies in rheumatoid arthritis.Journal of ultrasonography · 2012Review
- The impact of MRI on the clinical management of inflammatory arthritides.Skeletal radiology · 2011Review
- Emerging MRI methods in rheumatoid arthritis.Nature reviews. Rheumatology · 2011Review
- Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T.Magma (New York, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveDynamic contrast-enhanced MRI of patients with rheumatoid arthritis has shown a decrease in the early enhancement rate (EER) of synovitis after treatment. The purpose of this work was to investigate the underlying changes.
methods3D dynamic contrast-enhanced images were acquired from 13 patients before and 1-2 weeks after anti-TNF alpha treatment. The EER of the inflamed synovium was measured. The T1 relaxation time of the synovitis was calculated from images at different flip angles. The time course of the arrival of gadolinium at the radial artery was determined. The gadolinium enhancement of the inflamed synovium was modeled to calculate the fractional plasma volume (vp), the fractional extravascular, extracellular fluid volume (ve), and the volume transfer constant (Ktrans). Pre- and post-treatment values were compared and the dependence of the EER on each parameter was assessed.
resultsThere was a decrease in the EER measured over 26 s after treatment (29%, p = 0.002). Reductions in T1 (12%, p = 0.001), Ktrans (31%, p = 0.002), and vp (43%, p = 0.01) contributed to this; however, the EER was relatively insensitive to changes in ve.
conclusionsThe decrease in EER after anti-TNF alpha treatment is largely caused by reductions in the volume transfer constant Ktrans, the fractional plasma volume vp, and the T1 relaxation time. Only the contributions from Ktrans and vp directly reflect synovial vascularity.
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