ReviewJournal of molecular neuroscience : MN2008
The cytoskeleton in oligodendrocytes. Microtubule dynamics in health and disease.
Review in Journal of molecular neuroscience : MN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology.Frontiers in neurology · 2020Pooled it
- Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health.Life (Basel, Switzerland) · 2025Review
- Diversity, Functional Complexity, and Translational Potential of Glial Cells in the Central Nervous System.International journal of molecular sciences · 2025Review
- Single-Cell RNA-Seq Uncovers Robust Glial Cell Transcriptional Changes in Methamphetamine-Administered Mice.International journal of molecular sciences · 2025Article
- Tubulin Cytoskeleton in Neurodegenerative Diseases-not Only Primary Tubulinopathies.Cellular and molecular neurobiology · 2023Review
- Article
- Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord.Cell reports · 2022Article
- Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?Molecular neurobiology · 2021Review
- Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases.Frontiers in neuroscience · 2021Review
- Alzheimer's and Consciousness: How Much Subjectivity Is Objective?Neuroscience insights · 2021Article
- Review
- Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery.Nature communications · 2020Article
- A Role of Microtubules in Oligodendrocyte Differentiation.International journal of molecular sciences · 2020Article
- Galectin-3 Exerts a Pro-differentiating and Pro-myelinating Effect Within a Temporal Window Spanning Precursors and Pre-oligodendrocytes: Insights into the Mechanisms of Action.Molecular neurobiology · 2020Article
- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.Nature medicine · 2020Article
- Oligodendrocytes in intracerebral hemorrhage.CNS neuroscience & therapeutics · 2019Review
- Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies.Frontiers in aging neuroscience · 2019Article
- Microtubule defects in mesenchymal stromal cells distinguish patients with Progressive Supranuclear Palsy.Journal of cellular and molecular medicine · 2018Article
- Microglia: Housekeeper of the Central Nervous System.Cellular and molecular neurobiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligodendrocytes have a complex cytoarchitecture and are characterized by an elaborate network of microtubules. They provide the tracks for organelle trafficking and the intracellular translocation of myelin-specific gene products. The integrity of the cytoskeleton is an essential determinant of the function and survival of oligodendrocytes. Microtubule growth and stability are regulated by microtubule-associated proteins. Oligodendrocytes contain a number of microtubule-associated proteins, including the tau proteins, which are developmentally regulated and especially prominent in the branching points of the cellular processes. Process outgrowth is regulated by the interaction of Fyn kinase with the cytoskeleton and by microtubule-severing proteins, such as stathmin. Alterations or disruption of the cytoskeleton and abundant abnormal aggregates of cytoskeletal proteins often accompany neurodegenerative diseases, and inclusion bodies, resembling protein aggregates found in neurons, are prominent in oligodendroglial lesions in white matter pathology. This review emphasizes the role of the cytoskeleton, particularly of microtubules and their associated proteins, in oligodendrocytes during developmental processes. Furthermore, recent data on protein aggregate formation in oligodendroglial cells, which might occur during aging and disease processes, are summarized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.