ArticleClinical & experimental metastasis2008
Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.
Article in Clinical & experimental metastasis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Quantitative proteomics identifies and validates urinary biomarkers of rhabdomyosarcoma in children.Clinical proteomics · 2023Article
- Secretome profiling ofFrontiers in oncology · 2023Article
- SPARC: a potential target for functional nanomaterials and drugs.Frontiers in molecular biosciences · 2023Review
- Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space.International journal of molecular sciences · 2022Article
- The Mammary Gland: Basic Structure and Molecular Signaling during Development.International journal of molecular sciences · 2022Review
- Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells.BMC cancer · 2021Article
- Downregulation of SPARC Expression Decreases Cell Migration and Invasion Involving Epithelial-Mesenchymal Transition through the p-FAK/p-ERK Pathway in Esophageal Squamous Cell Carcinoma.Journal of Cancer · 2020Article
- Review
- Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone.The Journal of biological chemistry · 2016Article
- High SPARC Expression Starting from Dysplasia, Associated with Breast Carcinoma, Is Predictive for Bone Metastasis without Enhancement of Plasma Levels.International journal of molecular sciences · 2015Article
- Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.Cell reports · 2014Article
- Bone matrix osteonectin limits prostate cancer cell growth and survival.Matrix biology : journal of the International Society for Matrix Biology · 2012Article
- The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.Molecular & cellular proteomics : MCP · 2012Article
- Integrin β4 regulates SPARC protein to promote invasion.The Journal of biological chemistry · 2012Article
- Anti-cancer role of SPARC, an inhibitor of adipogenesis.Cancer treatment reviews · 2011Review
- Augmented osteolysis in SPARC-deficient mice with bone-residing prostate cancer.Neoplasia (New York, N.Y.) · 2011Article
- Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression.International journal of cancer · 2010Review
- Extracellular matrix composition reveals complex and dynamic stromal-epithelial interactions in the mammary gland.Journal of mammary gland biology and neoplasia · 2010Review
- Lymphangiogenesis and lymphatic metastasis in breast cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Secreted protein, acidic and rich in cysteine (SPARC, also known as osteonectin or BM-40) is a glycoprotein component of the extracellular matrix that has been reported to be involved with a variety of cellular processes. Although SPARC expression levels are frequently altered in a variety of tumor types, the exact implications of deregulated SPARC expression--whether it promotes, inhibits or has no effect on tumor progression--have remained unclear. Our recent gene expression analyses have shown that SPARC is significantly downregulated in highly metastatic human prostate cancer cells. To test the role of endogenous SPARC in tumorigenesis directly, we examined cancer progression and metastasis in SPARC(+/-) and SPARC(-/-) mice using two separate transgenic mouse tumor models: transgenic adenocarcinoma of the mouse prostate (TRAMP) and murine mammary tumor virus-polyoma middle T (MMTV-PyMT). Surprisingly, in both instances, we found that loss of SPARC had no significant effects on tumor initiation, progression or metastasis. Tumor angiogenesis and collagen deposition were also largely unaffected. Our results indicate that, although differential SPARC expression may be a useful marker of aggressive, metastasis-prone tumors, loss of SPARC is not sufficient either to promote or to inhibit cancer progression in two spontaneous mouse tumor models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.