ArticleIndian journal of pediatrics2007
Ionized magnesium and gestational age.
Article in Indian journal of pediatrics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis.Nutrients · 2017Pooled it
- Magnesium sulfate tocolysis and intraventricular hemorrhage in very preterm infants.Indian journal of pediatrics · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigation of magnesium (Mg) homeostasis has re-emerged as an area of interest in preterm born neonates who are at risk for brain pathology. However, data regarding the association between the biologically active ionized form of Mg and gestational age (GA) at an early stage of life in newborn infants are controversial.
methodsWe evaluated the total and ionized Mg electrolyte (TMg and IMg) as well as the calcium (TCa and ICa) and pH in the cord blood and on day 2 of life in 22 neonates born at different gestational ages (< 32, 32-34 and > or =35 week) without magnesium tocolysis and absence of serious complications during pregnancy and delivery.
resultsThe IMg fraction that accounted for 68.1+/-5.1% of the TMg in the cord blood and 67.9+/-4.5% of the TMg on day 2 of life, was significantly higher in very preterm infants (GA< 32 week) as compared to neonates with GA > 35 week. Higher IMg levels were correlated with the lower pH that was recorded in the cord blood of the very preterm infants (correlation coefficient, r=-0.80, p< 0.0001) and ICa (r = -0.52, P< 0.01). Lower pH also was correlated with the GA (P< 0.0001). However, standard multiple regression analysis showed significant association between IMg levels and decreased pH but not the gestational age or ICa (beta=-1.10+/-0.21, p< 0.00009).
conclusionExtremely preterm infants even without additional exposure to tocolytic magnesium are at risk for the lower pH associated elevation of ionized Mg, which should be considered during the management of these infants in order to prevent hypermagnesemia-related pathology.
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