ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
76 citing papers in PubMed, 140 citations in OpenAlex.
- Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Article
- Neural stem cells transplantation combined with ethyl stearate promotes the activation of quiescent NSCs and improves PD rats motor behavior.Animal models and experimental medicine · 2026Article
- Specific neuroblast-derived signals control both cell migration and fate in the rostral migratory stream.bioRxiv : the preprint server for biology · 2025Article
- Suppression of Hippocampal Neurogenesis and Oligodendrocyte Maturation Similar to Developmental Hypothyroidism by Maternal Exposure of Rats to Ammonium Perchlorate, a Gunpowder Raw Material and Known Environmental Contaminant.Environmental toxicology · 2025Article
- Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration.Epigenetics · 2024Article
- Implementation of the Methyl-Seq platform to identify tissue- and sex-specific DNA methylation differences in the rat epigenome.Epigenetics · 2024Article
- Master regulators of neurogenesis: the dynamic roles of Ephrin receptors across diverse cellular niches.Translational psychiatry · 2024Review
- EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory.Cellular and molecular life sciences : CMLS · 2024Article
- Physical exercise restores adult neurogenesis deficits induced by simulated microgravity.NPJ microgravity · 2024Article
- Extended range proteomic analysis of blood plasma from schizophrenia patients.Frontiers in molecular biosciences · 2024Article
- Disrupted in Schizophrenia 1 Reverse Ectopic Migration of Neural Precursors in Mouse Hilus After Pilocarpine-Induced Status Epilepticus.Molecular neurobiology · 2023Article
- Gene therapy using genome-edited iPS cells for targeting malignant glioma.Bioengineering & translational medicine · 2023Article
- Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications.BMC genomics · 2023Article
- Activation of ephrinb1/EPHB2/MAP-2/NMDAR Mediates Hippocampal Neurogenesis Promoted by Transcranial Direct Current Stimulation in Cerebral-Ischemic Mice.Neuromolecular medicine · 2021Article
- Ulk4, a Newly Discovered Susceptibility Gene for Schizophrenia, Regulates Corticogenesis in Mice.Frontiers in cell and developmental biology · 2021Article
- Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach.Science advances · 2020Article
- Neuroinflammation and Neurogenesis in Alzheimer's Disease and Potential Therapeutic Approaches.International journal of molecular sciences · 2020Review
- Whole-BodyInternational journal of molecular sciences · 2018Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The adult brain maintains two regions of neurogenesis from which new neurons are born, migrate to their appropriate location, and become incorporated into the circuitry of the CNS. One of these, the subgranular zone of the hippocampal dentate gyrus, is of primary interest because of the role of this region in learning and memory. We show that mice lacking EphB1, and more profoundly EphB1 and EphB2, have significantly fewer neural progenitors in the hippocampus. Furthermore, other aspects of neurogenesis, such as polarity, cell positioning, and proliferation are disrupted in animals lacking the EphB1 receptor or its cognate ephrin-B3 ligand. Our data strongly suggest that EphB1 and ephrin-B3 cooperatively regulate the proliferation and migration of neural progenitors in the hippocampus and should be added to a short list of candidate target molecules for modulating the production and integration of new neurons as a treatment for neurodegenerative diseases or brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.