ArticleDiabetes care2008
Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
Article in Diabetes care, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02889510 (Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicentre Randomized Double Blind, Crossover, Placebo Controlled Clinical Trial to Evaluate the Effect of Liraglutide on Lung Function in Patients With Type 2 Diabetes Mellitus (LIRALUNG Study)
Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- Pooled it
- HbA1c and pulmonary function in type 2 diabetes mellitus: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review.Respiratory research · 2021Pooled it
- Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Trial
- Type 2 Diabetes and the Lung - Cause and Consequence.Current diabetes reports · 2026Review
- Glycemic Alterations in Hospitalized COVID-19 Patients: Hyperglycemia and Newly Detected Diabetes.Epidemiologia (Basel, Switzerland) · 2026Article
- Underweight Status Amplifies Respiratory Infection Mortality in Diabetes: Findings From a Nationwide Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Proteomic Profiling of Pulmonary Function and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2026Observational
- The effect of type 2 diabetes on the prognosis of community-acquired pneumonia.Frontiers in endocrinology · 2026Article
- Mortality Trends in Patients Aged 25 and Older With Comorbid COPD and Diabetes Mellitus in the United States: A CDC WONDER Database Study From 2000 to 2023.Canadian respiratory journal · 2026Article
- Associations of the Charlson comorbidity index with asthma and mortality (NHANES 2007-2018): a cross-sectional study.Journal of health, population, and nutrition · 2025Observational
- Influence of Exercise on Oxygen Consumption, Pulmonary Ventilation, and Blood Gas Analyses in Individuals with Chronic Diseases.Life (Basel, Switzerland) · 2025Review
- Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes.Journal of personalized medicine · 2025Article
- Type 2 Diabetes Mellitus: A Metabolic Model of Accelerated Aging - Multi-Organ Mechanisms and Intervention Approaches.Aging and disease · 2025Review
- The role of type 2 diabetes in the severity of adult asthma.Current opinion in allergy and clinical immunology · 2025Review
- Diabetic pulmonary microangiopathy and its association with glycated haemoglobin and other diabetic complications.Bioinformation · 2025Article
- Effects of Diabetes Mellitus and Glycemic Traits on COPD and Pulmonary Function Traits: Insights From Mendelian Randomization and NHANES.International journal of chronic obstructive pulmonary disease · 2025Article
- Article
- Relationship between diabetes-related clinical characteristics and preserved ratio impaired spirometry (PRISm): findings from NHANES 2007-2012.BMJ public health · 2024Article
- Unraveling the Link between Ιnsulin Resistance and Bronchial Asthma.Biomedicines · 2024Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally. RESEARCH DESIGN AND
methodsWe conducted cross-sectional and prospective analyses of diabetes status and lung function decline using baseline and 3-year follow-up data on 1,100 diabetic and 10,162 nondiabetic middle-aged adults from the Atherosclerosis Risk in Communities (ARIC) Study. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) were measured at baseline and at the 3-year follow-up using standard spirometry.
resultsAt baseline, adults with diabetes had significantly lower predicted FVC (96 vs. 103%, P < 0.001) and predicted FEV(1) (92 vs. 96%, P < 0.001) than those without diabetes. These differences remained significant after adjustment for demographic characteristics, adiposity, smoking, physical activity index, education, and ARIC field center. Graded, inverse associations were observed between hyperglycemia, diabetes severity (i.e., duration of diabetes and types of antidiabetes medications), and FVC and FEV(1) (all P(trend) < 0.001). In prospective analyses, FVC declined faster in diabetic adults than in their nondiabetic counterparts (64 vs. 58 ml/year, P = 0.01). Diabetes severity as indicated by intensity of antidiabetic treatment also showed graded relationships with the rate of FVC decline (P < 0.01).
conclusionsThese data support the notion that the lung is a target organ for diabetic injury. Additional research is required to identify pathophysiologic mechanisms and to determine clinical significance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.