ArticleProceedings of the National Academy of Sciences of the United States of America2007
A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Trends in circadian rhythms research in fungi since the millenium.Npj biological timing and sleep · 2026Review
- Individual peroxiredoxin or Tor pathway components are not required for circadian clock function in Neurospora crassa.Fungal biology · 2025Article
- Circadian rhythms: pervasive, and often times evasive.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Transcriptional rewiring of an evolutionarily conserved circadian clock.The EMBO journal · 2024Article
- Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase.Microbiology spectrum · 2023Article
- Circadian oscillations ineLife · 2022Article
- A global search for novel transcription factors impacting the Neurospora crassa circadian clock.G3 (Bethesda, Md.) · 2021Article
- Habitat-Specific Clock Variation and Its Consequence on Reproductive Fitness.Journal of biological rhythms · 2020Article
- Principles of the animal molecular clock learned from Neurospora.The European journal of neuroscience · 2020Review
- Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.Current genetics · 2019Review
- Making Time: Conservation of Biological Clocks from Fungi to Animals.Microbiology spectrum · 2017Review
- Article
- period-1 encodes an ATP-dependent RNA helicase that influences nutritional compensation of the Neurospora circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.Science (New York, N.Y.) · 2015Article
- Article
- The circadian clock of Neurospora crassa.FEMS microbiology reviews · 2012Review
- A new mutation affecting FRQ-less rhythms in the circadian system of Neurospora crassa.PLoS genetics · 2011Article
- The genetics of circadian rhythms in Neurospora.Advances in genetics · 2011Review
- FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.Genetics · 2010Article
- Circadian output, input, and intracellular oscillators: insights into the circadian systems of single cells.Cold Spring Harbor symposia on quantitative biology · 2007Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In Neurospora, metabolic oscillators coexist with the circadian transcriptional/translational feedback loop governed by the FRQ (Frequency) and WC (White Collar) proteins. One of these, a choline deficiency oscillator (CDO) observed in chol-1 mutants grown under choline starvation, drives an uncompensated long-period developmental cycle ( approximately 60-120 h). To assess possible contributions of this metabolic oscillator to the circadian system, molecular and physiological rhythms were followed in liquid culture under choline starvation, but these only confirmed that an oscillator with a normal circadian period length can run under choline starvation. This finding suggested that long-period developmental cycles elicited by nutritional stress could be masking output from the circadian system, although a caveat was that the CDO sometimes requires several days to become consolidated. To circumvent this and observe both oscillators simultaneously, we used an assay using a codon-optimized luciferase to follow the circadian oscillator. Under conditions where the long-period, uncompensated, CDO-driven developmental rhythm was expressed for weeks in growth tubes, the luciferase rhythm in the same cultures continued in a typical compensated manner with a circadian period length dependent on the allelic state of frq. Periodograms revealed no influence of the CDO on the circadian oscillator. Instead, the CDO appears as a cryptic metabolic oscillator that can, under appropriate conditions, assume control of growth and development, thereby masking output from the circadian system. frq-driven luciferase as a reporter of the circadian oscillator may in this way provide a means for assessing prospective role(s) of metabolic and/or ancillary oscillators within cellular circadian systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.