ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- The Research Progress of DNA Methylation in the Development and Function of the Porcine Placenta.International journal of molecular sciences · 2024Review
- Article
- Review
- Augmented glucose production is not contingent on high catecholamines in fetal sheep with IUGR.The Journal of endocrinology · 2021Article
- Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.American journal of physiology. Endocrinology and metabolism · 2019Article
- Pulsatile hyperglycemia increases insulin secretion but not pancreatic β-cell mass in intrauterine growth-restricted fetal sheep.Journal of developmental origins of health and disease · 2018Article
- DNA methylation patterns and gene expression associated with litter size in Berkshire pig placenta.PloS one · 2017Article
- Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production.Molecular and cellular endocrinology · 2016Article
- Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses.American journal of physiology. Endocrinology and metabolism · 2016Article
- Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.American journal of physiology. Endocrinology and metabolism · 2015Article
- Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep.American journal of physiology. Endocrinology and metabolism · 2014Article
- Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase β-cell mass in fetal sheep.American journal of physiology. Endocrinology and metabolism · 2013Article
- Increased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supply.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin.Diabetes · 2013Article
- A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway.Journal of virology · 2011Article
- The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes.Seminars in reproductive medicine · 2011Review
- Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on {beta}1- and {beta}2-adrenergic receptors in the fetal baboon liver.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Catecholamines mediate multiple fetal adaptations during placental insufficiency that contribute to intrauterine growth restriction: lessons from hyperthermic sheep.Journal of pregnancy · 2011Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Hepatic glucose production is normally activated at birth but has been observed in response to experimental hypoglycemia in fetal sheep. The cellular basis for this process remains unknown. We determined the impact of 2 wk of fetal hypoglycemia during late gestation on enzymes responsible for hepatic gluconeogenesis, focusing on the insulin-signaling pathway, transcription factors, and coactivators that regulate gluconeogenesis. Hepatic phosphoenolpyruvate carboxykinase and glucose-6-phosphatase mRNA increased 12-fold and 7-fold, respectively, following chronic hypoglycemia with no change in hepatic glycogen. Chronic hypoglycemia decreased fetal plasma insulin with no change in glucagon but increased plasma cortisol 3.5-fold. Peroxisome proliferator-activated receptor-gamma coactivator-1alpha mRNA and phosphorylation of cAMP response element binding protein at Ser(133) were both increased, with no change in Akt, forkhead transcription factor FoxO1, hepatocyte nuclear factor-4alpha, or CCAAT enhancer binding protein-beta. These results demonstrate that chronic fetal hypoglycemia triggers signals that can activate gluconeogenesis in the fetal liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.