ArticleProceedings of the National Academy of Sciences of the United States of America2007
The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA.EMBO reports · 2026Article
- Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells.PLoS genetics · 2022Article
- New resources for the Drosophila 4th chromosome: FRT101F enabled mitotic clones and Bloom syndrome helicase enabled meiotic recombination.G3 (Bethesda, Md.) · 2022Article
- Nutrient Sensing via Gut inInternational journal of molecular sciences · 2022Review
- The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.Nature communications · 2022Article
- Insects as a New Complex Model in Hormonal Basis of Obesity.International journal of molecular sciences · 2021Review
- Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.Frontiers in endocrinology · 2021Article
- The Glucagon-Like Adipokinetic Hormone inFrontiers in physiology · 2021Review
- Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation ofFrontiers in endocrinology · 2021Article
- Control of lifespan and survival byAging · 2020Article
- Metabolism and growth adaptation to environmental conditions in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions.Cell and tissue research · 2020Review
- Growth regulation by amino acid transporters in Drosophila larvae.Cellular and molecular life sciences : CMLS · 2020Review
- Regulation of insulin and adipokinetic hormone/glucagon production in flies.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion.Nature communications · 2019Article
- Drosophila FIT is a protein-specific satiety hormone essential for feeding control.Nature communications · 2017Article
- Extracellular CADM1 interactions influence insulin secretion by rat and human islet β-cells and promote clustering of syntaxin-1.American journal of physiology. Endocrinology and metabolism · 2016Article
- The Systemic Control of Growth.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Obesity-linked homologues TfAP-2 and Twz establish meal frequency in Drosophila melanogaster.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Single-cell resolution lineage information is a critical key to understanding how the states of gene regulatory networks respond to cell interactions and thereby establish distinct cell fates. Here, we identify a single pair of neural stem cells (neuroblasts) as progenitors of the brain insulin-producing neurosecretory cells of Drosophila, which are homologous to islet beta cells. Likewise, we identify a second pair of neuroblasts as progenitors of the neurosecretory Corpora cardiaca cells, which are homologous to the glucagon-secreting islet alpha cells. We find that both progenitors originate as neighboring cells from anterior neuroectoderm, which expresses genes orthologous to those expressed in the vertebrate adenohypophyseal placode, the source of endocrine anterior pituitary and neurosecretory hypothalamic cells [Whitlock KE (2005) Trends Endocrinol Metab 16:145-151]. This ontogenic-molecular concordance suggests that a rudimentary brain endocrine axis was present in the common ancestor of humans and flies, where it orchestrated the islet-like endocrine functions of insulin and glucagon biology.
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