ArticleThe Journal of experimental medicine2007
Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Altered 3D chromatin structure permits inversional recombination at theScience advances · 2020Article
- Misregulation of theFrontiers in immunology · 2018Article
- CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Immunology · 2013Review
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.Nature immunology · 2012Article
- The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1.The Journal of experimental medicine · 2012Article
- Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Epigenetic and 3-dimensional regulation of V(D)J rearrangement of immunoglobulin genes.Seminars in immunology · 2010Review
- Antigen receptor allelic exclusion: an update and reappraisal.Journal of immunology (Baltimore, Md. : 1950) · 2010Review
- The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.The Journal of biological chemistry · 2010Article
- Review
- An activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Advances in immunology · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Complete IgHC gene rearrangement occurs only in B cells in a stage-specific and ordered manner. We used gene targeting to reposition a distal V(H) gene segment to a region just 5' of the D(H) gene cluster and found its activation to be highly dependent on the chromosomal domain within which it resides. The targeted V(H) gene segment rearranged at a higher frequency than its endogenous counterpart, its rearrangement was no longer ordered, and its ability to be silenced by allelic exclusion was lost. Additionally, the targeted V(H) gene segment lost lineage specificity, as VDJ(H) rearrangement was observed in thymocytes. These data suggest that locus contraction, mimicked by proximal targeting, can override any regulation imposed by DNA sequences immediately surrounding V(H) gene segments.
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