Evidence map›Paper›PMID 18056272›Full record

ArticleAntimicrobial agents and chemotherapy2008

Vancomycin-resistant Staphylococcus aureus isolates associated with Inc18-like vanA plasmids in Michigan.

Wenming Zhu, Nancye C Clark, Linda K McDougal, Jeffery Hageman, L Clifford McDonald, Jean B Patel

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Review
  2. Clarifying the Dual Role ofFoods (Basel, Switzerland) · 2025
    Review
  3. Antibiotics (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Vancomycin Resistance inMicroorganisms · 2022
    Review
  6. Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022
    Review
  7. Antibiotics (Basel, Switzerland) · 2022
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Antibacterial efficacy ofVeterinary world · 2019
    Article
  15. Article
  16. Review
  17. Envelope Structures of Gram-Positive Bacteria.Current topics in microbiology and immunology · 2017
    Review
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenming ZhuDivision of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS-G08, Atlanta, GA 30333, USA.
Nancye C Clark
Linda K McDougal
Jeffery Hageman
L Clifford McDonald
Jean B Patel

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Five of the seven cases of vancomycin-resistant Staphylococcus aureus (VRSA) infection identified to date have occurred in southeastern Michigan. VRSA isolates from the four most recent cases (all from Michigan) were characterized. The vanA gene was localized to a single plasmid in each VRSA isolate. The pulsed-field gel electrophoresis patterns of chromosomal DNA and the restriction profile of the plasmid demonstrated that the four isolates were unique and differed from the first three VRSA isolates. Vancomycin-resistant Enterococcus (VRE) isolates, all of which were Enterococcus faecalis, were recovered from case patients 4 to 6. Each VRE isolate transferred vancomycin resistance to E. faecalis JH2-2 by conjugation. PCRs for vanA and the Inc18-like plasmid genes traA and repR confirmed the presence of an Inc18-like vanA plasmid in all VRE isolates and transconjugants. An Inc18-like vanA plasmid was identified in the VRSA isolate from case patient 7. These findings suggest a role of Inc18-like plasmids as vanA donors.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCarbon-Oxygen LigasesConjugation, GeneticDNA, BacterialDNA Transposable ElementsElectrophoresis, Gel, Pulsed-FieldEnterococcus faecalisHumansMichiganMicrobial Sensitivity TestsPlasmidsPolymerase Chain ReactionRestriction MappingStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsCarbon-Oxygen LigasesDNA, BacterialDNA Transposable ElementsVanA ligase, Bacteria

Identifiers

PMID18056272
PMCPMC2224762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.