ArticleMolecular biology and evolution2008
Adaptive evolution of proteins secreted during sperm maturation: an analysis of the mouse epididymal transcriptome.
Article in Molecular biology and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Mating system variation and gene expression in the male reproductive tract of Peromyscus mice.Molecular ecology · 2025Article
- Cell Compartment is a Predictor of Protein Rate of Evolution, but not in the Manner Expected: Evidence Against the Extended Complexity Hypothesis.Genome biology and evolution · 2025Article
- Comparative Genomics Supports Ecologically Induced Selection as a Putative Driver of Banded Penguin Diversification.Molecular biology and evolution · 2024Article
- Seminal fluid gene expression and reproductive fitness in Drosophila melanogaster.BMC ecology and evolution · 2022Article
- Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes†.Biology of reproduction · 2021Article
- Nonadaptive molecular evolution of seminal fluid proteins in Drosophila.Evolution; international journal of organic evolution · 2021Article
- Molecular Evolution of Ecological Specialisation: Genomic Insights from the Diversification of Murine Rodents.Genome biology and evolution · 2021Article
- Buffalo sperm surface proteome profiling reveals an intricate relationship between innate immunity and reproduction.BMC genomics · 2021Article
- Importance of SLC26 Transmembrane Anion Exchangers in Sperm Post-testicular Maturation and Fertilization Potential.Frontiers in cell and developmental biology · 2019Review
- Positive Selection in the Evolution of Mammalian CRISPs.Journal of molecular evolution · 2018Article
- Genes Integral to the Reproductive Function of Male Reproductive Tissues Drive Heterogeneity in Evolutionary Rates in Japanese Quail.G3 (Bethesda, Md.) · 2018Article
- Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera.BMC genomics · 2017Article
- Comparative Sperm Proteomics in Mouse Species with Divergent Mating Systems.Molecular biology and evolution · 2017Article
- Article
- Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem Cells.Biology of reproduction · 2015Article
- Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly.BMC genomics · 2015Article
- No evidence of conpopulation sperm precedence between allopatric populations of house mice.PloS one · 2014Article
- Proteins involved in motility and sperm-egg interaction evolve more rapidly in mouse spermatozoa.PloS one · 2014Article
- Patterns of transcriptome divergence in the male accessory gland of two closely related species of field crickets.Genetics · 2013Article
- Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus.Molecular ecology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A common pattern observed in molecular evolution is that reproductive genes tend to evolve rapidly. However, most previous studies documenting this rapid evolution are based on genes expressed in just a few male reproductive organs. In mammals, sperm become motile and capable of fertilization only after leaving the testis, during their transit through the epididymis. Thus, genes expressed in the epididymis are expected to play important roles in male fertility. Here, we performed evolutionary genetic analyses on the epididymal transcriptome of mice. Overall, epididymis-expressed genes showed evidence of strong evolutionary constraint, a finding that contrasts with most previous analyses of genes expressed in other male reproductive organs. However, a subset of epididymis-specialized, secreted genes showed several signatures of adaptive evolution, including an increased rate of nonsynonymous evolution. Furthermore, this subset of genes was overrepresented on the X chromosome. Immunity and protein modification functions were significantly overrepresented among epididymis-specialized, secreted genes. These analyses identified a group of genes likely to be important in male reproductive success.
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