ArticleInvestigative ophthalmology & visual science2007
Characterization of Wnt signaling during photoreceptor degeneration.
Article in Investigative ophthalmology & visual science, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Axin1 stabilizes S-opsin and maintains cone photoreceptor survival by inhibiting GSK3β activity.Cell death discovery · 2026Article
- Article
- Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity.Cold Spring Harbor perspectives in medicine · 2022Review
- Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Endolymphatic Hydrop Phenotype in Familial Norrie Disease Caused by Large Fragment Deletion ofFrontiers in aging neuroscience · 2022Article
- The neuroprotective role of Wnt signaling in the retina.Neural regeneration research · 2021Article
- CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue.Antioxidants (Basel, Switzerland) · 2021Article
- WNT5B in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
- The effect of extrinsic Wnt/β-catenin signaling in Muller glia on retinal ganglion cell neurite growth.Developmental neurobiology · 2020Article
- Wnt signaling induces neurite outgrowth in mouse retinal ganglion cells.Experimental eye research · 2019Article
- Wnt Signaling in vascular eye diseases.Progress in retinal and eye research · 2019Review
- A growing field: The regulation of axonal regeneration by Wnt signaling.Neural regeneration research · 2018Review
- Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse.Neuroscience · 2017Article
- Downregulation of the Canonical WNT Signaling Pathway by TGFβ1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics.Stem cells and development · 2016Article
- Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration.Neuropharmacology · 2015Article
- The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.Experimental eye research · 2014Review
- Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell.In vitro cellular & developmental biology. Animal · 2013Article
- Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish.Molecular biology and evolution · 2013Article
- Muller glia in retinal innate immunity: a perspective on their roles in endophthalmitis.Critical reviews in immunology · 2013Review
- Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway.Neuroreport · 2012Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe Wnt pathway is an essential signaling cascade that regulates multiple processes in developing and adult tissues, including differentiation, cellular survival, and stem cell proliferation. The authors recently demonstrated altered expression of Wnt pathway genes during photoreceptor death in rd1 mice, suggesting an involvement for Wnt signaling in the disease process. In this study, the authors investigated the role of Wnt signaling in retinal degeneration.
methodsThe Wnt signaling reporter mouse line Tcf-LacZ was crossed with retinal degeneration rd1 mice, and beta-galactosidase expression was used to localize Wnt signaling during photoreceptor death. To analyze the role of Wnt signaling activation, primary mixed retinal cultures were prepared, and XTT and TUNEL assays were used to quantify cell death. Luciferase reporter assays were used to measure Wnt signaling.
resultsThe canonical Wnt signaling pathway was activated in Müller glia and the ganglion cell layer during rod photoreceptor degeneration in rd1/Tcf-LacZ mice. Wnt signaling was confirmed in cultured primary Müller glia. Furthermore, Wnt signaling activators protected photoreceptors in primary retinal cultures from H(2)O(2)-induced oxidative stress. The Wnt ligands Wnt5a, Wnt5b, Wnt10a, and Wnt13 were expressed in the degenerating retina and are candidate Wnt signaling activators in vivo.
conclusionsThis study is the first demonstration that Wnt signaling is activated in the degenerating retina and that it protects retinal cultures from oxidative stress. These data suggest that Wnt signaling is a component of the glial protective response during photoreceptor injury. Therefore, inducing Wnt activation, alone or in combination with growth factors, may increase the threshold for apoptosis and halt or delay further photoreceptor degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.