ArticleThe American journal of pathology2007
Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.
Article in The American journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- The ILK-PINCH-parvin complex: a conserved primary adhesome regulating biological processes.Histochemistry and cell biology · 2025Review
- Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness.PloS one · 2025Article
- Hidden pathway: the role of extracellular matrix in type 2 diabetes mellitus-related sarcopenia.Frontiers in endocrinology · 2025Review
- Requirement for PINCH in skeletal myoblast differentiation.Cell and tissue research · 2023Article
- Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake.The Journal of physiology · 2022Review
- Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome.Disease models & mechanisms · 2021Article
- Review
- Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy.American journal of physiology. Cell physiology · 2019Review
- Evidence for skeletal muscle fiber type-specific expressions of mechanosensors.Cellular and molecular life sciences : CMLS · 2019Article
- Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia.Aging and disease · 2018Article
- PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.Human molecular genetics · 2017Article
- Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.Skeletal muscle · 2017Article
- Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.Diabetes · 2016Article
- Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover.Physiological genomics · 2015Article
- The extracellular matrix and insulin resistance.Trends in endocrinology and metabolism: TEM · 2015Review
- Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.eLife · 2014Article
- The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy.The FEBS journal · 2013Review
- Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality.Disease models & mechanisms · 2013Article
- Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway.American journal of physiology. Endocrinology and metabolism · 2013Article
- Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.Molecular & cellular proteomics : MCP · 2013Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Integrin-linked kinase (Ilk) is a serine/threonine kinase and an adaptor protein that links integrins to the actin cytoskeleton and to a number of signaling pathways involved in integrin action. We hypothesized that Ilk may act as an important effector of integrins in skeletal muscle, where these receptors provide a critical link between the sarcolemma and the extracellular matrix. Using the cre/lox system, we deleted Ilk from skeletal muscles of mice. The resulting mutants developed a progressive muscular dystrophy with multiple degenerating and regenerating muscle fibers, increased central nuclei, and endomysial fibrosis. These defects were widespread but were most severe near myofascial junctions where Ilk mutants showed displacement of focal adhesion-related proteins, including vinculin, paxillin, focal adhesion kinase, dystrophin, and the alpha 7 beta 1D-integrin subunits. Distal ends of mutant muscle fibers appeared irregular, and there was restructuring of the actin cytoskeleton. These findings resemble those seen in humans and mice lacking the alpha 7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of these deficiencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.