ArticleBMJ (Clinical research ed.)2007
New point of care Chlamydia Rapid Test--bridging the gap between diagnosis and treatment: performance evaluation study.
Article in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03767231 (Emergency Department Patient's Perceptions and Acceptability Toward a Novel Point-of-Care Hepatitis C Virus Viral Load Testing), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Emergency Department Patient's Perceptions and Acceptability Toward a Novel Point-of-Care Hepatitis C Virus Viral Load Testing
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Rapid point of care test for detecting urogenital Chlamydia trachomatis infection in nonpregnant women and men at reproductive age.The Cochrane database of systematic reviews · 2020Pooled it
- Obtaining self-samples to diagnose curable sexually transmitted infections: a systematic review of patients' experiences.PloS one · 2015Pooled it
- What can be learnt from a qualitative evaluation of implementing a rapid sexual health testing, diagnosis and treatment service?BMJ open · 2021Article
- Performance of point-of-care tests for the detection of chlamydia trachomatis infections: A systematic review and meta-analysis.EClinicalMedicine · 2021Article
- Comparison of real-time PCR assay with a commercial rapid test based on the immunochromatographic principle for the detection ofLe infezioni in medicina · 2021Article
- Light Forge: A Microfluidic DNA Melting-based Tuberculosis Test.The journal of applied laboratory medicine · 2020Article
- Lost opportunity to save newborn lives: variable national antenatal screening policies for Neisseria gonorrhoeae and Chlamydia trachomatis.International journal of STD & AIDS · 2017Article
- Highly sensitive and novel point-of-care system, aQcare Chlamydia TRF kit for detecting Chlamydia trachomatis by using europium (Eu) (III) chelated nanoparticles.Annals of laboratory medicine · 2015Article
- Article
- Point of care diagnostics for sexually transmitted infections: perspectives and advances.Expert review of anti-infective therapy · 2014Review
- An early evaluation of clinical and economic costs and benefits of implementing point of care NAAT tests for Chlamydia trachomatis and Neisseria gonorrhoea in genitourinary medicine clinics in England.Sexually transmitted infections · 2014Article
- Advances and challenges in biosensor-based diagnosis of infectious diseases.Expert review of molecular diagnostics · 2014Review
- Blind evaluation of the microwave-accelerated metal-enhanced fluorescence ultrarapid and sensitive Chlamydia trachomatis test by use of clinical samples.Journal of clinical microbiology · 2013Article
- Comparative effectiveness of a rapid point-of-care test for detection of Chlamydia trachomatis among women in a clinical setting.Sexually transmitted infections · 2013Article
- Prevalence of genital Chlamydia infection in urban women of reproductive age, Nairobi, Kenya.BMC research notes · 2013Article
- Article
- A multiplexed microfluidic PCR assay for sensitive and specific point-of-care detection of Chlamydia trachomatis.PloS one · 2012Article
- Applying new technologies for diagnosing sexually transmitted infections in resource-poor settings.Sexually transmitted infections · 2011Article
- Acceptability of self-testing for trichomoniasis increases with experience.Sexually transmitted infections · 2011Article
- Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal.PLoS neglected tropical diseases · 2011Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
objectiveTo evaluate the performance of a new Chlamydia Rapid Test with vaginal swab specimens as a potential tool for chlamydia diagnosis and screening.
designPerformance evaluation study. Settings A young people's sexual health centre (site 1) and two genitourinary medicine clinics (sites 2 and 3) in the United Kingdom.
participants1349 women aged between 16 and 54 attending one of the three clinics.
main outcome measuresSensitivity, specificity, positive predictive value, and negative predictive value of the Chlamydia Rapid Test versus polymerase chain reaction and strand displacement amplification assays; correlation between the Chlamydia Rapid Test visual signal and organism load; acceptability to participants of self collected vaginal swabs as the specimen type for Chlamydia testing.
resultsPolymerase chain reaction positivity rates for Chlamydia trachomatis infection were 8.4% (56/663) at site 1, 9.4% (36/385) at site 2, and 6.0% (18/301) at site 3. Compared with polymerase chain reaction assay, the resolved sensitivity, specificity, positive predictive value, and negative predictive value of the Chlamydia Rapid Test were 83.5% (91/109), 98.9% (1224/1238), 86.7% (91/105), and 98.6% (1224/1242). Compared with strand displacement amplification assay, sensitivity and specificity of the Chlamydia Rapid Test were 81.6% (40/49) and 98.3% (578/588). Organism load of self collected vaginal swabs ranged from 5.97x10(2) to 1.09x10(9) Chlamydia plasmids per swab, which correlated well with the Chlamydia Rapid Test's visual signal (r=0.6435, P<0.0001). Most (95.9%) surveyed participants felt comfortable about collecting their own swabs.
conclusionsThe performance of the Chlamydia Rapid Test with self collected vaginal swabs indicates that it would be an effective same day diagnostic and screening tool for Chlamydia infection in women. The availability of Chlamydia Rapid Test results within 30 minutes allows for immediate treatment and contact tracing, potentially reducing the risks of persistent infection and onward transmission. It could also provide a simple and reliable alternative to nucleic acid amplification tests in chlamydia screening programmes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.