ArticleThe Kaohsiung journal of medical sciences2007
Association of apolipoprotein E polymorphism with ischemic stroke subtypes in Taiwan.
Article in The Kaohsiung journal of medical sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Apolipoprotein EDisease markers · 2022Pooled it
- Meta-analysis of APOE ε2/ε3/ε4 polymorphism and cerebral infarction.Journal of neural transmission (Vienna, Austria : 1996) · 2013Pooled it
- Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.Bioscience reports · 2017Article
- Genetics of ischaemic stroke in young adults.BBA clinical · 2015Review
- Genetics of stroke.Acta pharmacologica Sinica · 2010Review
- Apolipoprotein E polymorphism in normal Han Chinese population: frequency and effect on lipid parameters.Molecular biology reports · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to clarify whether the apolipoprotein E gene (APOE) is related to ischemic stroke subtypes in Taiwan's Chinese population. Using the classification of Cerebrovascular Diseases III, 143 patients with lacunar infarction, 114 patients with atherothrombotic infarction, and 112 healthy controls were enrolled. APOE genotype was determined using polymerase chain reaction. Regarding the distribution of APOE genotypes, the frequency of epsilon3/epsilon4 genotypes in lacunar patients was significantly different from that in control subjects, by logistic regression, using epsilon3/epsilon3 as a reference group. There was no significant difference between atherothrombotic patients and the control group in the distribution of APOE genotypes or alleles. The present finding suggests that there is a probable association between epsilon3/epsilon4 genotype and lacunar infarcts, but not atherothrombotic infarcts. This indicates that genetic factors may play a role, at least partially, in lacunar infarction in Taiwan's Chinese population.
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