ArticleNeuron2007
Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion.
Article in Neuron, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 90 citations in OpenAlex.
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- TGF-β Family Signaling inCold Spring Harbor perspectives in biology · 2017Review
- Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons.Nature communications · 2017Article
- Analyzing Dendritic Morphology in Columns and Layers.Journal of visualized experiments : JoVE · 2017Article
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- Mapping chromatic pathways in the Drosophila visual system.The Journal of comparative neurology · 2016Article
- Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development.eLife · 2015Article
- Strategies for exploring TGF-β signaling in Drosophila.Methods (San Diego, Calif.) · 2014Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
The organization of neuronal wiring into layers and columns is a common feature of both vertebrate and invertebrate brains. In the Drosophila visual system, each R7 photoreceptor axon projects within a single column to a specific layer of the optic lobe. We refer to the restriction of terminals to single columns as tiling. In a genetic screen based on an R7-dependent behavior, we identified the Activin receptor Baboon and the nuclear import adaptor Importin-alpha3 as being required to prevent R7 axon terminals from overlapping with the terminals of R7s in neighboring columns. This tiling function requires the Baboon ligand, dActivin, the transcription factor, dSmad2, and retrograde transport from the growth cone to the R7 nucleus. We propose that dActivin is an autocrine signal that restricts R7 growth cone motility, and we demonstrate that it acts in parallel with a paracrine signal that mediates repulsion between R7 terminals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.