ArticleCell metabolism2007
Mitochondria and aging: dilution is the solution.
Article in Cell metabolism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism.Nature metabolism · 2026Article
- NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin.Nature metabolism · 2020Article
- Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans.Scientific reports · 2018Article
- Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The redox stress hypothesis of aging.Free radical biology & medicine · 2012Review
- A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.PLoS biology · 2010Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic component depletion in model systems results in life-span extension, which has been difficult to reconcile with human metabolic pathologies. Recently, Rea et al. (2007) have shown that mitochondrial electron transport chain RNAi phenotypes in the worm C. elegans are dose dependent, providing an alternative view of mitochondrial function in longevity and metabolic diseases.
Indexed as
Identifiers
18054312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.